Impairments of contrast discrimination and contrast adaptation in glaucoma

McKendrick, Allison M., Sampson, Geoff P., Walland, Mark J. and Badcock, David R. 2010, Impairments of contrast discrimination and contrast adaptation in glaucoma, Investigative ophthalmology & visual science, vol. 51, no. 2, pp. 920-927, doi: 10.1167/iovs.08-3332.

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Title Impairments of contrast discrimination and contrast adaptation in glaucoma
Author(s) McKendrick, Allison M.
Sampson, Geoff P.ORCID iD for Sampson, Geoff P. orcid.org/0000-0003-0145-5691
Walland, Mark J.
Badcock, David R.
Journal name Investigative ophthalmology & visual science
Volume number 51
Issue number 2
Start page 920
End page 927
Total pages 8
Publisher Association for Research in Vision and Ophthalmology
Place of publication Rockville, Maryland
Publication date 2010-02
ISSN 1552-5783
0146-0404
Keyword(s) contrast detection
contrast adaptation
glaucoma
discrimination
Summary Purpose:
Contrast detection is commonly measured clinically; however, discrimination between contrasts is also important for natural vision. Furthermore, optimal performance requires the visual system to adapt to ambient contrast conditions. Recent studies of primate neurophysiology demonstrate significant retinal involvement in contrast adaptation. This study was conducted to investigate whether glaucoma alters contrast adaptation. Both detection and discrimination task performance were examined.

Methods:
Psychophysical contrast detection and discrimination thresholds were measured in central vision, for a vertically oriented D6 centered on 3 cyc/deg. Thresholds were measured with and without adaptation to low (15%)- and high (70%)-contrast, vertically oriented, 3-cyc/deg sinusoidal gratings. Fifteen people with glaucoma, and 15 age-similar control subjects participated. Full-contrast discrimination (dipper) functions were measured for a subset (three patients with glaucoma and three control subjects).

Results:
On average, the glaucoma group showed elevated detection and discrimination thresholds relative to control subjects (detection: t(28) = 2.42; P = 0.02; discrimination: F1,28 = 6.157, P = 0.02). For the subset of additionally tested participants, normalized contrast discrimination functions were similarly shaped for all observers. Glaucoma group thresholds were less influenced by contrast adaptation than were control subjects, for discrimination (F1,28 = 10.89, P < 0.01) but not detection (F1,28 = 2.28; P = 0.11). Differences between groups were greatest for low-contrast stimuli (significant interaction between contrast and group: P < 0.01).

Conclusions:
Glaucoma alters the effect of contrast adaptation on discrimination performance, particularly at low contrast. The study of suprathreshold aspects of vision may reveal new insights into the pathophysiology of glaucoma and possibly relate better to real-world visual performance than detection measures.
Language eng
DOI 10.1167/iovs.08-3332
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2010, Association for Research in Vision and Ophthalmology
Persistent URL http://hdl.handle.net/10536/DRO/DU:30066316

Document type: Journal Article
Collections: Faculty of Health
School of Health and Social Development
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