Abnormal mitochondrial L-arginine transport contributes to the pathogenesis of heart failure and rexoygenation injury Williams, David, Venardos, Kylie M., Byrne, Melissa, Joshi, Mandar, Horlock, Duncan, Lam, Nicholas T., Gregorevic, Paul, McGee, Sean L. and Kaye, David M. 2014, Abnormal mitochondrial L-arginine transport contributes to the pathogenesis of heart failure and rexoygenation injury, PLoS one, vol. 9, no. 8, Article number : e104643, pp. 1-11, doi: 10.1371/journal.pone.0104643. Attached Files Name Description MIMEType Size Downloads venardos-abnormal-2014.pdf Published version application/pdf 988.23KB 151 Title Abnormal mitochondrial L-arginine transport contributes to the pathogenesis of heart failure and rexoygenation injury Author(s) Williams, David Venardos, Kylie M. Byrne, Melissa Joshi, Mandar Horlock, Duncan Lam, Nicholas T. Gregorevic, Paul McGee, Sean L. orcid.org/0000-0001-6953-106X Kaye, David M. Journal name PLoS one Volume number 9 Issue number 8 Season Article number : e104643 Start page 1 End page 11 Total pages 11 Publisher Public Library of Science Place of publication San Francisco, CA Publication date 2014-08-11 ISSN 1932-6203 Keyword(s) Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics NITRIC-OXIDE SYNTHASE ISCHEMIA-REPERFUSION INJURY ISOLATED CARDIAC MITOCHONDRIA MYOCARDIAL-ISCHEMIA COMPLEX-I ENDOTHELIAL-CELLS METABOLIC STATES AMINO-ACIDS MODULATION BIOGENESIS Summary Impaired mitochondrial function is fundamental feature of heart failure (HF) and myocardial ischemia. In addition to the effects of heightened oxidative stress, altered nitric oxide (NO) metabolism, generated by a mitochondrial NO synthase, has also been proposed to impact upon mitochondrial function. However, the mechanism responsible for arginine transport into mitochondria and the effect of HF on such a process is unknown. We therefore aimed to characterize mitochondrial L-arginine transport and to investigate the hypothesis that impaired mitochondrial L-arginine transport plays a key role in the pathogenesis of heart failure and myocardial injury. Language eng DOI 10.1371/journal.pone.0104643 Field of Research 119999 Medical and Health Sciences not elsewhere classified Socio Economic Objective 920103 Cardiovascular System and Diseases HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2014, Public Library of Science Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30067306 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Connect to Elements publication management system Go to link with your DU access privileges   Connect to published version Go to link with your DU access privileges   Author URL Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Tue, 11 Nov 2014, 13:00:07 EST Mon, 08 Dec 2014, 14:29:46 EST Mon, 08 Dec 2014, 15:08:13 EST Mon, 08 Dec 2014, 15:21:56 EST Wed, 17 Dec 2014, 12:30:46 EST Wed, 17 Dec 2014, 12:32:26 EST Thu, 18 Dec 2014, 13:35:40 EST Thu, 18 Dec 2014, 13:36:40 EST Wed, 14 Oct 2015, 13:56:02 EST Wed, 07 Sep 2016, 07:56:04 EST Wed, 06 Dec 2017, 06:10:31 EST Fri, 07 Sep 2018, 17:20:47 EST Filtered Full Citation counts:   Cited 13 times in TR Web of Science Cited 14 times in Scopus Search Google Scholar Access Statistics: 847 Abstract Views, 152 File Downloads  -  Detailed Statistics Created: Mon, 08 Dec 2014, 14:29:46 EST