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The STARS signaling pathway: a key regulator of skeletal muscle function

Lamon,S, Wallace,MA and Russell,AP 2014, The STARS signaling pathway: a key regulator of skeletal muscle function, Pflügers archiv - European journal of physiology, vol. 466, no. 9, pp. 1659-1671, doi: 10.1007/s00424-014-1475-5.

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Title The STARS signaling pathway: a key regulator of skeletal muscle function
Author(s) Lamon,SORCID iD for Lamon,S orcid.org/0000-0002-3271-6551
Wallace,MA
Russell,AP
Journal name Pflügers archiv - European journal of physiology
Volume number 466
Issue number 9
Start page 1659
End page 1671
Publisher Springer
Place of publication Heidelberg, Germany
Publication date 2014-09
ISSN 1432-2013
Keyword(s) ABRA
MS1
Skeletal muscle
STARS
Science & Technology
Life Sciences & Biomedicine
Physiology
SERUM-RESPONSE FACTOR
UBIQUITIN-PROTEASOME PATHWAY
FOCAL ADHESION KINASE
RHO-FAMILY GTPASES
ALPHA-ACTIN GENE
MYOGENIC DIFFERENTIATION
SATELLITE CELL
SMOOTH-MUSCLE
FACTOR SRF
TRANSCRIPTIONAL COACTIVATORS
Summary During the last decade, the striated muscle activator of Rho signaling (STARS), a muscle-specific protein, has been proposed to play an increasingly important role in skeletal muscle growth, metabolism, regeneration and stress adaptation. STARS influences actin dynamics and, as a consequence, regulates the myocardin-related transcription factor A/serum response factor (MRTF-A/SRF) transcriptional program, a well-known pathway controlling skeletal muscle development and function. Muscle-specific stress conditions, such as exercise, positively regulates, while disuse and degenerative muscle diseases are associated with a downregulation of STARS and its downstream partners, suggesting a pivotal role for STARS in skeletal muscle health. This review provides a comprehensive overview of the known role and regulation of STARS and the members of its signaling pathway, RhoA, MRTF-A and SRF, in skeletal muscle.
Language eng
DOI 10.1007/s00424-014-1475-5
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis)
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30067308

Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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Citation counts: TR Web of Science Citation Count  Cited 15 times in TR Web of Science
Scopus Citation Count Cited 20 times in Scopus Google Scholar Search Google Scholar
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Created: Mon, 08 Dec 2014, 14:03:41 EST

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