The STARS signaling pathway: a key regulator of skeletal muscle function Lamon,S, Wallace,MA and Russell,AP 2014, The STARS signaling pathway: a key regulator of skeletal muscle function, Pflügers archiv - European journal of physiology, vol. 466, no. 9, pp. 1659-1671, doi: 10.1007/s00424-014-1475-5. Attached Files Name Description MIMEType Size Downloads Title The STARS signaling pathway: a key regulator of skeletal muscle function Author(s) Lamon,S orcid.org/0000-0002-3271-6551 Wallace,MA Russell,AP Journal name Pflügers archiv - European journal of physiology Volume number 466 Issue number 9 Start page 1659 End page 1671 Publisher Springer Place of publication Heidelberg, Germany Publication date 2014-09 ISSN 1432-2013 Keyword(s) ABRA MS1 Skeletal muscle STARS Science & Technology Life Sciences & Biomedicine Physiology SERUM-RESPONSE FACTOR UBIQUITIN-PROTEASOME PATHWAY FOCAL ADHESION KINASE RHO-FAMILY GTPASES ALPHA-ACTIN GENE MYOGENIC DIFFERENTIATION SATELLITE CELL SMOOTH-MUSCLE FACTOR SRF TRANSCRIPTIONAL COACTIVATORS Summary During the last decade, the striated muscle activator of Rho signaling (STARS), a muscle-specific protein, has been proposed to play an increasingly important role in skeletal muscle growth, metabolism, regeneration and stress adaptation. STARS influences actin dynamics and, as a consequence, regulates the myocardin-related transcription factor A/serum response factor (MRTF-A/SRF) transcriptional program, a well-known pathway controlling skeletal muscle development and function. Muscle-specific stress conditions, such as exercise, positively regulates, while disuse and degenerative muscle diseases are associated with a downregulation of STARS and its downstream partners, suggesting a pivotal role for STARS in skeletal muscle health. This review provides a comprehensive overview of the known role and regulation of STARS and the members of its signaling pathway, RhoA, MRTF-A and SRF, in skeletal muscle. Language eng DOI 10.1007/s00424-014-1475-5 Field of Research 119999 Medical and Health Sciences not elsewhere classified Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis) HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2014, Springer Persistent URL http://hdl.handle.net/10536/DRO/DU:30067308 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Related Links Link Description Connect to Elements publication management system Go to link with your DU access privileges   Connect to published version Go to link with your DU access privileges   Author URL Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Tue, 11 Nov 2014, 13:25:37 EST Mon, 08 Dec 2014, 14:03:41 EST Mon, 08 Dec 2014, 15:08:20 EST Mon, 08 Dec 2014, 15:20:41 EST Thu, 11 Dec 2014, 08:12:02 EST Thu, 11 Dec 2014, 08:12:53 EST Thu, 11 Dec 2014, 11:30:17 EST Filtered Full Citation counts:   Cited 15 times in TR Web of Science Cited 20 times in Scopus Search Google Scholar Access Statistics: 766 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Mon, 08 Dec 2014, 14:03:41 EST