The STARS signaling pathway: a key regulator of skeletal muscle function
Lamon,S, Wallace,MA and Russell,AP 2014, The STARS signaling pathway: a key regulator of skeletal muscle function, Pflügers archiv - European journal of physiology, vol. 466, no. 9, pp. 1659-1671, doi: 10.1007/s00424-014-1475-5.
Attached Files
Name
Description
MIMEType
Size
Downloads
Title
The STARS signaling pathway: a key regulator of skeletal muscle function
During the last decade, the striated muscle activator of Rho signaling (STARS), a muscle-specific protein, has been proposed to play an increasingly important role in skeletal muscle growth, metabolism, regeneration and stress adaptation. STARS influences actin dynamics and, as a consequence, regulates the myocardin-related transcription factor A/serum response factor (MRTF-A/SRF) transcriptional program, a well-known pathway controlling skeletal muscle development and function. Muscle-specific stress conditions, such as exercise, positively regulates, while disuse and degenerative muscle diseases are associated with a downregulation of STARS and its downstream partners, suggesting a pivotal role for STARS in skeletal muscle health. This review provides a comprehensive overview of the known role and regulation of STARS and the members of its signaling pathway, RhoA, MRTF-A and SRF, in skeletal muscle.
Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.