Growth restriction in the rat alters expression of cardiac JAK/STAT genes in a sex-specific manner.

van der Linde,S, Romano,T, Wadley,G, Jeffries,AJ, Wlodek,ME and Hryciw,DH 2014, Growth restriction in the rat alters expression of cardiac JAK/STAT genes in a sex-specific manner., Journal of developmental origins of health and disease, vol. 5, no. 4, pp. 314-321, doi: 10.1017/S2040174414000245.

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Title Growth restriction in the rat alters expression of cardiac JAK/STAT genes in a sex-specific manner.
Author(s) van der Linde,S
Wadley,GORCID iD for Wadley,G
Journal name Journal of developmental origins of health and disease
Volume number 5
Issue number 4
Start page 314
End page 321
Total pages 28
Publisher Cambridge University Press
Place of publication England, London
Publication date 2014-08
ISSN 2040-1752
Keyword(s) born small
Summary Uteroplacental insufficiency resulting in intrauterine growth restriction has been associated with the development of cardiovascular disease, coronary heart disease and increased blood pressure, particularly in males. The molecular mechanisms that result in the programming of these phenotypes are not clear. This study investigated the expression of cardiac JAK/STAT signalling genes in growth restricted offspring born small due to uteroplacental insufficiency. Bilateral uterine vessel ligation was performed on day 18 of pregnancy to induce growth restriction (Restricted) or sham surgery (Control). Cardiac tissue at embryonic day (E) 20, postnatal day (PN) 1, PN7 and PN35 in male and female Wistar (WKY) rats (n=7-10 per group per age) was isolated and mRNA extracted. In the heart, there was an effect of age for males for all genes examined there was a decrease in expression after PN1. With females, JAK2 expression was significantly reduced after E20, while PI3K in females was increased at E30 and PN35. Further, mRNA expression was significantly altered in JAK/STAT signalling targets in Restricteds in a sex-specific manner. Compared with Controls, in males, JAK2 and STAT3 were significantly reduced in the Restricted, while in females SOCS3 was significantly increased and PI3K significantly decreased in the Restricted offspring. Finally, there were specific differences in the levels of gene expression within the JAK/STAT pathway when comparing males to females. Thus, growth restriction alters specific targets in the JAK/STAT signalling pathway, with altered JAK2 and STAT3 potentially contributing to the increased risk of cardiovascular disease in the growth restricted males.
Language eng
DOI 10.1017/S2040174414000245
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 920103 Cardiovascular System and Diseases
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2014, Cambridge University Press
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