Adipokines as emerging depression biomarkers: a systematic review and meta-analysis

Carvalho,AF, Rocha,DQC, McIntyre,RS, Mesquita,LM, Köhler,CA, Hyphantis,TN, Sales,PMG, Machado-Vieira,R and Berk,M 2014, Adipokines as emerging depression biomarkers: a systematic review and meta-analysis, Journal of psychiatric research, vol. 59, pp. 28-37, doi: 10.1016/j.jpsychires.2014.08.002.

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Title Adipokines as emerging depression biomarkers: a systematic review and meta-analysis
Author(s) Carvalho,AF
Berk,MORCID iD for Berk,M
Journal name Journal of psychiatric research
Volume number 59
Start page 28
End page 37
Publisher Elsevier
Place of publication Oxford, England
Publication date 2014-12-01
ISSN 0022-3956
Keyword(s) Adiponectin
Major depressive disorder
Summary Adiponectin, leptin and resistin may play a role in the pathophysiology of major depressive disorder (MDD). However, differences in peripheral levels of these hormones are inconsistent across diagnostic and intervention studies. Therefore, we performed meta-analyses of diagnostic studies (i.e., MDD subjects versus healthy controls) and intervention investigations (i.e., pre-vs. post-antidepressant treatment) in MDD. Adiponectin (N=1278; Hedge's g=-0.35; P=0.16) and leptin (N=893; Hedge's g=-0.018; P=0.93) did not differ across diagnostic studies. Meta-regression analyses revealed that gender and depression severity explained the heterogeneity observed in adiponectin diagnostic studies, while BMI and the difference in BMI between MDD individuals and controls explained the heterogeneity of leptin diagnostic studies. Subgroup analyses revealed that adiponectin peripheral levels were significantly lower in MDD participants compared to controls when assayed with RIA, but not ELISA. Leptin levels were significantly higher in individuals with mild/moderate depression versus controls. Resistin serum levels were lower in MDD individuals compared to healthy controls (N=298; Hedge's g=-0.25; P=0.03). Leptin serum levels did not change after antidepressant treatment. However, heterogeneity was significant and sample size was low (N=108); consequently meta-regression analysis could not be performed. Intervention meta-analyses could not be performed for adiponectin and resistin (i.e., few studies met inclusion criteria). In conclusion, this systematic review and meta-analysis underscored that relevant moderators/confounders (e.g., BMI, depression severity and type of assay) should be controlled for when considering the role of leptin and adiponectin as putative MDD diagnostic biomarkers.
Language eng
DOI 10.1016/j.jpsychires.2014.08.002
Field of Research 111714 Mental Health
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Elsevier
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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