Vascular contribution to metastasis Sax,M, Plummer,PN, Mittal,V and Mellick,AS 2014, Vascular contribution to metastasis, Cancer forum, vol. 38, no. 2, 5, pp. 103-107. Attached Files Name Description MIMEType Size Downloads sax-vascular-2014.pdf Published version application/pdf 319.23KB 71 Title Vascular contribution to metastasis Author(s) Sax,M Plummer,PN Mittal,V Mellick,AS Journal name Cancer forum Volume number 38 Issue number 2 Season 5 Start page 103 End page 107 Publisher Cancer Council Australia Place of publication Sydney, N.S.W. Publication date 2014-07 ISSN 0311-306X Summary It has been 40 years since Folkman's seminal paper [Cancer Res 1974. 34:2109-13], proposing the presence of a tumour associated angiogenic factor, which could be targeted as an anticancer therapy. There are currently a handful of drugs in trial or use that have been marketed as targeting angiogenesis. Unfortunately, the most widely used of these, bevacizumab (Avastin™, Roche), has met with limited success clinically. For this reason and based on a calculation of cost benefit, bevacizumab is now only publically subsidised for use in a limited range of solid tumours. That the contribution of vasculature to malignancy remains poorly understood is increasingly clear. At the same time, the traditional view that vascularisation is a passive participant in the process of malignancy, and that endothelium merely provides a conduit by which tumour cells spread, is being replaced with an understanding that vasculature is a key player in the process of metastasis. Furthermore, the identification of non-traditional sources of vasculature has complicated our understanding of the tumour endothelium as a unique population that can be simply targeted as an anticancer therapy. The following review seeks to provide an up-to-date view of vascular contribution to metastasis and implications for new vasculature-targeted anticancer treatments. Language eng Field of Research 111201 Cancer Cell Biology Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2014, Cancer Council Australia Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30068214 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Fri, 12 Dec 2014, 14:17:59 EST Sat, 13 Dec 2014, 04:02:01 EST Thu, 08 Jan 2015, 05:05:19 EST Fri, 16 Jan 2015, 08:30:45 EST Fri, 16 Jan 2015, 08:32:40 EST Fri, 16 Jan 2015, 08:35:58 EST Fri, 16 Jan 2015, 08:37:22 EST Thu, 22 Jan 2015, 11:37:19 EST Tue, 03 Feb 2015, 08:00:14 EST Tue, 03 Mar 2015, 11:33:45 EST Wed, 07 Sep 2016, 08:07:46 EST Wed, 12 Apr 2017, 13:08:30 EST Wed, 06 Dec 2017, 10:40:52 EST Fri, 07 Sep 2018, 17:44:53 EST Filtered Full Citation counts:   Cited 1 times in TR Web of Science Cited 1 times in Scopus Search Google Scholar Access Statistics: 149 Abstract Views, 72 File Downloads  -  Detailed Statistics Created: Fri, 12 Dec 2014, 14:17:59 EST