Identification of MicroRNAs linked to regulators of muscle protein synthesis and regeneration in young and old skeletal muscle Zacharewicz, Evelyn, Della Gatta, Paul, Reynolds, John, Garnham, Andrew, Crowley, Tamsyn, Russell, Aaron P. and Lamon, Severine 2014, Identification of MicroRNAs linked to regulators of muscle protein synthesis and regeneration in young and old skeletal muscle, PLoS One, vol. 9, no. 12, Article Number : e114009, pp. 1-25, doi: 10.1371/journal.pone.0114009. Attached Files Name Description MIMEType Size Downloads zacharewicz-identificationof-2014.pdf Published version application/pdf 1.63MB 166 Title Identification of MicroRNAs linked to regulators of muscle protein synthesis and regeneration in young and old skeletal muscle Author(s) Zacharewicz, Evelyn Della Gatta, Paul orcid.org/0000-0003-2231-8370 Reynolds, John Garnham, Andrew Crowley, Tamsyn orcid.org/0000-0002-3698-8917 Russell, Aaron P. orcid.org/0000-0002-7323-9501 Lamon, Severine orcid.org/0000-0002-3271-6551 Journal name PLoS One Volume number 9 Issue number 12 Season Article Number : e114009 Start page 1 End page 25 Total pages 25 Publisher PLoS Place of publication San Francisco, Calif. Publication date 2014 ISSN 1932-6203 Summary Over the course of ageing there is a natural and progressive loss of skeletal muscle mass. The onset and progression of age-related muscle wasting is associated with an attenuated activation of Akt-mTOR signalling and muscle protein synthesis in response to anabolic stimuli such as resistance exercise. MicroRNAs (miRNAs) are novel and important post-transcriptional regulators of numerous cellular processes. The role of miRNAs in the regulation of muscle protein synthesis following resistance exercise is poorly understood. This study investigated the changes in skeletal muscle miRNA expression following an acute bout of resistance exercise in young and old subjects with a focus on the miRNA species predicted to target Akt-mTOR signalling. Language eng DOI 10.1371/journal.pone.0114009 Field of Research 110699 Human Movement and Sports Science not elsewhere classified Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis) HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2014, PLoS Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30068982 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences School of Medicine Institute for Physical Activity and Nutrition Open Access Collection Related Links Link Description Connect to Elements publication management system Go to link with your DU access privileges   Connect to published version Go to link with your DU access privileges   Author URL Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Tue, 13 Jan 2015, 12:59:05 EST Tue, 13 Jan 2015, 12:59:54 EST Wed, 14 Jan 2015, 04:00:35 EST Wed, 14 Jan 2015, 05:06:04 EST Thu, 22 Jan 2015, 11:10:02 EST Thu, 22 Jan 2015, 11:11:40 EST Thu, 22 Jan 2015, 11:17:32 EST Tue, 03 Feb 2015, 07:47:23 EST Fri, 06 Feb 2015, 11:33:23 EST Thu, 05 Mar 2015, 13:57:04 EST Wed, 01 Jul 2015, 15:16:58 EST Mon, 06 Jul 2015, 08:42:37 EST Mon, 06 Jul 2015, 08:47:39 EST Wed, 14 Oct 2015, 14:09:13 EST Wed, 07 Sep 2016, 08:13:31 EST Wed, 06 Dec 2017, 06:12:06 EST Fri, 07 Sep 2018, 17:23:50 EST Filtered Full Citation counts:   Cited 58 times in TR Web of Science Cited 60 times in Scopus Search Google Scholar Access Statistics: 707 Abstract Views, 167 File Downloads  -  Detailed Statistics Created: Tue, 13 Jan 2015, 12:59:54 EST