Nucleic acid aptamer-guided cancer therapeutics and diagnostics: the next generation of cancer medicine Xiang, Dongxi, Shigdar, Sarah, Qiao, Greg, Wang, Tao, Kouzani, Abbas Z., Zhou, Shu-Feng, Kong, Lingxue, Li, Yong, Pu,Chuwen and Duan, Wei 2015, Nucleic acid aptamer-guided cancer therapeutics and diagnostics: the next generation of cancer medicine, Theranostics, vol. 5, no. 1, pp. 23-42, doi: 10.7150/thno.10202. Attached Files Name Description MIMEType Size Downloads xiang-nucleicacidaptamer-2015.pdf Published version application/pdf 17.24MB 286 Title Nucleic acid aptamer-guided cancer therapeutics and diagnostics: the next generation of cancer medicine Author(s) Xiang, Dongxi Shigdar, Sarah orcid.org/0000-0001-8084-8447 Qiao, Greg Wang, Tao Kouzani, Abbas Z. orcid.org/0000-0002-6292-1214 Zhou, Shu-Feng Kong, Lingxue orcid.org/0000-0001-6219-3897 Li, Yong Pu,Chuwen Duan, Wei orcid.org/0000-0001-5782-9184 Journal name Theranostics Volume number 5 Issue number 1 Start page 23 End page 42 Total pages 20 Publisher Ivyspring International Place of publication Wyoming, N.S.W. Publication date 2015 ISSN 1838-7640 Keyword(s) active targeting aptamer cancer stem cell cancer theranostic cancer therapy chemoresistance Science & Technology Life Sciences & Biomedicine Medicine, Research & Experimental Research & Experimental Medicine CELL ADHESION MOLECULE MESOPOROUS SILICA NANOPARTICLES INTERSTITIAL FLUID PRESSURE ENDOTHELIAL GROWTH-FACTOR SPONTANEOUS ANIMAL TUMORS OVARIAN-CARCINOMA CELLS TARGETED DRUG-DELIVERY STEM-CELLS IN-VIVO BREAST-CANCER Summary Conventional anticancer therapies, such as chemo- and/or radio-therapy are often unable to completely eradicate cancers due to abnormal tumor microenvironment, as well as increased drug/radiation resistance. More effective therapeutic strategies for overcoming these obstacles are urgently in demand. Aptamers, as chemical antibodies that bind to targets with high affinity and specificity, are a promising new and novel agent for both cancer diagnostic and therapeutic applications. Aptamer-based cancer cell targeting facilitates the development of active targeting in which aptamer-mediated drug delivery could provide promising anticancer outcomes. This review is to update the current progress of aptamer-based cancer diagnosis and aptamer-mediated active targeting for cancer therapy in vivo, exploring the potential of this novel form of targeted cancer therapy. Language eng DOI 10.7150/thno.10202 Field of Research 090301 Biomaterials Socio Economic Objective 860803 Human Pharmaceutical Treatments (e.g. Antibiotics) HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2015, Ivyspring International Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30070168 Document type: Journal Article Collections: Faculty of Health School of Medicine Faculty of Science, Engineering and Built Environment School of Engineering Institute for Frontier Materials Open Access Collection GTP Research Related Links Link Description Connect to Elements publication management system Go to link with your DU access privileges   Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Tue, 03 Mar 2015, 09:33:51 EST Tue, 03 Mar 2015, 09:34:34 EST Tue, 03 Mar 2015, 09:35:09 EST Wed, 04 Mar 2015, 04:00:37 EST Wed, 08 Jul 2015, 06:05:42 EST Mon, 13 Jul 2015, 13:31:20 EST Mon, 13 Jul 2015, 13:40:06 EST Mon, 13 Jul 2015, 14:15:54 EST Tue, 14 Jul 2015, 09:03:37 EST Fri, 17 Jul 2015, 12:06:32 EST Mon, 12 Oct 2015, 15:54:25 EST Tue, 22 Mar 2016, 11:18:38 EST Wed, 07 Sep 2016, 08:34:28 EST Wed, 06 Dec 2017, 06:13:12 EST Fri, 07 Sep 2018, 17:26:18 EST Filtered Full Citation counts:   Cited 144 times in TR Web of Science Cited 156 times in Scopus Search Google Scholar Access Statistics: 1140 Abstract Views, 288 File Downloads  -  Detailed Statistics Created: Tue, 03 Mar 2015, 09:35:09 EST