Phylogenetic analysis of beak and feather disease virus across a host ring-species complex Eastwood,JR, Berg,ML, Ribot,RF, Raidal,SR, Buchanan,KL, Walder,KR and Bennett,AT 2014, Phylogenetic analysis of beak and feather disease virus across a host ring-species complex, Proceedings of the national scademy of sciences of the USA, vol. 111, no. 39, pp. 14153-14158, doi: 10.1073/pnas.1403255111. Attached Files Name Description MIMEType Size Downloads Title Phylogenetic analysis of beak and feather disease virus across a host ring-species complex Author(s) Eastwood,JR Berg,ML orcid.org/0000-0002-5774-3089 Ribot,RF orcid.org/0000-0003-3869-8873 Raidal,SR Buchanan,KL orcid.org/0000-0002-6648-5819 Walder,KR orcid.org/0000-0002-6758-4763 Bennett,AT orcid.org/0000-0001-8512-2805 Journal name Proceedings of the national scademy of sciences of the USA Volume number 111 Issue number 39 Start page 14153 End page 14158 Publisher National Academy of Sciences Place of publication Washington, DC Publication date 2014-09-30 ISSN 1091-6490 0027-8424 Keyword(s) crimson rosella heterosis host–pathogen coevolution psittacine circovirus sympatric speciation Host-pathogen coevolution Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics PSITTACINE BEAK HYBRID ZONE HUMAN MIGRATIONS WORMY MICE PARASITES RESISTANCE SPECIATION HYBRIDIZATION POPULATION INFECTION Summary Pathogens have been hypothesized to play a major role in host diversity and speciation. Susceptibility of hybrid hosts to pathogens is thought to be a common phenomenon that could promote host population divergence and subsequently speciation. However, few studies have tested for pathogen infection across animal hybrid zones while testing for codivergence of the pathogens in the hybridizing host complex. Over 8 y, we studied natural infection by a rapidly evolving single-strand DNA virus, beak and feather diseases virus (BFDV), which infects parrots, exploiting a host-ring species complex (Platycercus elegans) in Australia. We found that host subspecies and their hybrids varied strikingly in both BFDV prevalence and load: both hybrid and phenotypically intermediate subspecies had lower prevalence and load compared with parental subspecies, while controlling for host age, sex, longitude and latitude, as well as temporal effects. We sequenced viral isolates throughout the range, which revealed patterns of genomic variation analogous to Mayr's ring-species hypothesis, to our knowledge for the first time in any host-pathogen system. Viral phylogeny, geographic location, intraspecific host density, and parrot community diversity and composition did not explain the differences in BFDV prevalence or load between subpopulations. Overall, our analyses suggest that functional host responses to infection, or force of infection, differ between subspecies and hybrids. Our findings highlight the role of host hybridization and clines in altering host-pathogen interactions, dynamics that can have important implications for models of speciation with gene flow, and offer insights into how pathogens may adapt to diverging host populations. Language eng DOI 10.1073/pnas.1403255111 Field of Research 069999 Biological Sciences not elsewhere classified Socio Economic Objective 929999 Health not elsewhere classified HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2014, National Academy of Science Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30070249 Document type: Journal Article Collections: Faculty of Health School of Medicine Faculty of Science, Engineering and Built Environment School of Life and Environmental Sciences Open Access Collection Centre for Integrative Ecology Related Links Link Description Link to full-text (open access)   Connect to published version Go to link with your DU access privileges   Author URL Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Thu, 05 Mar 2015, 09:39:36 EST Fri, 06 Mar 2015, 04:02:18 EST Fri, 06 Mar 2015, 05:06:50 EST Thu, 12 Mar 2015, 13:27:23 EST Thu, 12 Mar 2015, 13:28:33 EST Thu, 12 Mar 2015, 13:30:11 EST Thu, 12 Mar 2015, 13:31:06 EST Tue, 17 Mar 2015, 12:57:49 EST Fri, 28 Oct 2016, 11:25:48 EST Sat, 09 Nov 2019, 19:41:01 EST Filtered Full Citation counts:   Cited 33 times in TR Web of Science Cited 35 times in Scopus Search Google Scholar Access Statistics: 609 Abstract Views, 8 File Downloads  -  Detailed Statistics Created: Thu, 05 Mar 2015, 09:39:36 EST

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