Restless leg syndrome associated with atypical antipsychotics : current status, pathophysiology, and clinical implications Aggarwal, Shilpa, Dodd, Seetal and Berk, Michael 2015, Restless leg syndrome associated with atypical antipsychotics : current status, pathophysiology, and clinical implications, Current drug safety, vol. 10, no. 2, pp. 98-105. Attached Files Name Description MIMEType Size Downloads Title Restless leg syndrome associated with atypical antipsychotics : current status, pathophysiology, and clinical implications Author(s) Aggarwal, Shilpa orcid.org/0000-0002-8590-0846 Dodd, Seetal orcid.org/0000-0002-7918-4636 Berk, Michael orcid.org/0000-0002-5554-6946 Journal name Current drug safety Volume number 10 Issue number 2 Start page 98 End page 105 Total pages 8 Publisher Bentham Science Publishers Place of publication San Francisco, Calif. Publication date 2015-07 ISSN 1574-8863 2212-3911 Summary Restless leg syndrome (RLS) is a common disorder, frequently of unclear origin, which is often associated with significant distress. There are a few case reports of atypical antipsychotic agents (AAP) causing RLS. The pathophysiological mechanisms resulting in emergence of these movements suggest central dopaminergic dysfunction. Dopamine agonists and L-dopa reduce the symptoms of RLS, and some agents that block the dopaminergic system aggravate RLS. Genetic influences are implicated in RLS and an association between gene polymorphisms and antipyschotic-associated onset of RLS has been postulated. Greater awareness of potential causes of RLS, and its differentiation from akathisia and illness-related agitation might help in reducing the distress associated with it and improving patient compliance in patients using atypical antipsychotic agents. Language eng Field of Research 110319 Psychiatry (incl Psychotherapy) 111714 Mental Health 1115 Pharmacology And Pharmaceutical Sciences 1103 Clinical Sciences 1104 Complementary And Alternative Medicine Socio Economic Objective 920410 Mental Health HERDC Research category C1.1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2015, Bentham Science Publishers Persistent URL http://hdl.handle.net/10536/DRO/DU:30071223 Document type: Journal Article Collections: Faculty of Health School of Medicine Related Links Link Description Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Wed, 18 Mar 2015, 08:58:45 EST Thu, 19 Mar 2015, 04:05:24 EST Thu, 19 Mar 2015, 07:51:27 EST Tue, 31 Mar 2015, 15:09:47 EST Fri, 09 Oct 2015, 17:08:39 EST Mon, 12 Oct 2015, 15:56:46 EST Fri, 03 Feb 2017, 05:00:38 EST Tue, 14 Feb 2017, 10:42:25 EST Tue, 14 Feb 2017, 10:43:35 EST Tue, 14 Feb 2017, 10:46:04 EST Mon, 29 Jan 2018, 13:00:48 EST Filtered Full Citation counts:   Cited 13 times in TR Web of Science Cited 14 times in Scopus Search Google Scholar Access Statistics: 536 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Wed, 18 Mar 2015, 08:58:45 EST