Restless leg syndrome associated with atypical antipsychotics : current status, pathophysiology, and clinical implications
Aggarwal, Shilpa, Dodd, Seetal and Berk, Michael 2015, Restless leg syndrome associated with atypical antipsychotics : current status, pathophysiology, and clinical implications, Current drug safety, vol. 10, no. 2, pp. 98-105.
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Restless leg syndrome associated with atypical antipsychotics : current status, pathophysiology, and clinical implications
Restless leg syndrome (RLS) is a common disorder, frequently of unclear origin, which is often associated with significant distress. There are a few case reports of atypical antipsychotic agents (AAP) causing RLS. The pathophysiological mechanisms resulting in emergence of these movements suggest central dopaminergic dysfunction. Dopamine agonists and L-dopa reduce the symptoms of RLS, and some agents that block the dopaminergic system aggravate RLS. Genetic influences are implicated in RLS and an association between gene polymorphisms and antipyschotic-associated onset of RLS has been postulated. Greater awareness of potential causes of RLS, and its differentiation from akathisia and illness-related agitation might help in reducing the distress associated with it and improving patient compliance in patients using atypical antipsychotic agents.
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eng
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110319 Psychiatry (incl Psychotherapy) 111714 Mental Health 1115 Pharmacology And Pharmaceutical Sciences 1103 Clinical Sciences 1104 Complementary And Alternative Medicine
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