The potential utility of a staging model as a course specifier: a bipolar disorder perspective.

Berk,M, Hallam,KT and McGorry,PD 2007, The potential utility of a staging model as a course specifier: a bipolar disorder perspective., Journal of Affective Disorders, vol. 100, no. 1-3, pp. 279-281, doi: 10.1016/j.jad.2007.03.007.

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Title The potential utility of a staging model as a course specifier: a bipolar disorder perspective.
Author(s) Berk,MORCID iD for Berk,M
Journal name Journal of Affective Disorders
Volume number 100
Issue number 1-3
Start page 279
End page 281
Publisher Elsevier
Place of publication Netherlands
Publication date 2007-06
ISSN 0165-0327
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences & Neurology
treatment resistance
early intervention
Summary Staging models are widely used in clinical medicine, and offer an insight into the progressive nature of many disorders. In general, the earlier stages of illness may be associated with a better prognosis and a higher treatment response. Once chronicity is reached, more complex and invasive treatments may be required, and the utility of treatments may decline. There is evidence that treatment response is greatest in the early phases of the disorder. There is also a progressive social and psychological burden of ongoing illness. This is paralleled by the twin notions of neuroprotection, which is supported by increasing evidence that structural changes in the disorder may be progressive and reversible with algorithm appropriate treatment, and that of early intervention, which posits that the optimal window for intervention is early in the illness course. A staging model compliments existing and proposed classifications of bipolar disorder, adding a temporal dimension to a cross sectional view. It may inform treatment choice and prognosis, and could have utility as a course specifier.
Language eng
DOI 10.1016/j.jad.2007.03.007
Field of Research 0 Not Applicable
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2007, Elsevier
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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