Platelet glutamate receptor supersensitivity in major depressive disorder. Berk,M, Plein,H and Ferreira,D 2001, Platelet glutamate receptor supersensitivity in major depressive disorder., Clinical Neuropharmacology, vol. 24, no. 3, pp. 129-132. Attached Files Name Description MIMEType Size Downloads Title Platelet glutamate receptor supersensitivity in major depressive disorder. Author(s) Berk,M orcid.org/0000-0002-5554-6946 Plein,H Ferreira,D Journal name Clinical Neuropharmacology Volume number 24 Issue number 3 Start page 129 End page 132 Publisher Lippincott, Williams & Wilkins Place of publication United States Publication date 2001-05 ISSN 0362-5664 Keyword(s) Science & Technology Life Sciences & Biomedicine Clinical Neurology Pharmacology & Pharmacy Neurosciences & Neurology depression psychosis platelet intracellular calcium response glutamate receptor supersensitivity mood N-methyl-D-aspartate EXCITATORY AMINO-ACIDS D-ASPARTATE RECEPTORS INTRACELLULAR CALCIUM SCHIZOPHRENIC-PATIENTS DOUBLE-BLIND MODEL ANTIDEPRESSANTS SEROTONIN GLYCINE PLASMA Summary Dysregulation of glutamate has been described in depression, and supersensitivity of platelet glutamate receptors has been found in both psychotic major depression and schizophrenia. The aim of this study was to examine the platelet glutamate receptor sensitivity in patients with nonpsychotic, unipolar major depression to assess whether this is a marker of depression or of psychosis. Glutamate receptor sensitivity was assessed using the platelet intracellular calcium response to glutamate (0-100 micromol) measured by spectrofluorometry. The depression group showed a significantly greater platelet intracellular calcium response to glutamate stimulation than the control group, both in terms of absolute values (p = 0.007) and percentage of response from baseline (p = 0.030). These data suggest that platelet glutamate receptors may be supersensitive in depression and that the platelet may be a possible peripheral marker of glutamate function in depression. Language eng Field of Research 0 Not Applicable Socio Economic Objective 0 Not Applicable HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2001, Lippincott, Williams & Wilkins Persistent URL http://hdl.handle.net/10536/DRO/DU:30071328 Document type: Journal Article Collections: Faculty of Health School of Medicine Related Links Link Description Author URL Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Wed, 18 Mar 2015, 10:26:44 EST Thu, 19 Mar 2015, 04:13:34 EST Thu, 19 Mar 2015, 05:15:33 EST Wed, 10 Jun 2015, 10:18:37 EST Wed, 10 Jun 2015, 10:19:23 EST Fri, 09 Oct 2015, 17:08:43 EST Mon, 12 Oct 2015, 15:58:39 EST Filtered Full Citation counts:   Cited 45 times in TR Web of Science Cited 47 times in Scopus Search Google Scholar Access Statistics: 479 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Wed, 18 Mar 2015, 10:26:44 EST

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