Serum levels of brain-derived neurotrophic factor in patients with schizophrenia and bipolar disorder.

Gama,CS, Andreazza,AC, Kunz,M, Berk,M, Belmonte-de-Abreu,PS and Kapczinski,F 2007, Serum levels of brain-derived neurotrophic factor in patients with schizophrenia and bipolar disorder., Neuroscience Letters, vol. 420, no. 1, pp. 45-48, doi: 10.1016/j.neulet.2007.04.001.

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Title Serum levels of brain-derived neurotrophic factor in patients with schizophrenia and bipolar disorder.
Author(s) Gama,CS
Berk,MORCID iD for Berk,M
Journal name Neuroscience Letters
Volume number 420
Issue number 1
Start page 45
End page 48
Publisher Elsevier
Place of publication Ireland
Publication date 2007-06
ISSN 1872-7972
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Neurosciences & Neurology
Summary There is evidence that major psychiatric discords such as schizophrenia (SZ) and bipolar disorder (BD) are associated with dysregulation of synaptic plasticity with downstream alterations of neurotrophins. Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in the central nervous system (CNS), and performs many biological functions such as promoting the survival, differentiation, and plasticity of neurons. Variants in the BDNF gene increase the risk of SZ and bipolar disorder. Chronic administration of drugs used to treat SZ and BD, such as lithium, valproate, quetiapine, clozapine, and olanzapine, increases BDNF expression in rat brain. To examine serum BDNF, three groups of chronically medicated DSM-IV SZ patients, on treatment with clozapine (n=27), typical (n=14), and other atypical antipsychotics (n=19), 30 euthymic BD patients, and 26 healthy control had 5 ml blood samples collected by venipuncture. Serum BDNF levels were significantly higher in SZ patients (p<0.001) when compared to either controls or euthymic BD patients. Increased BDNF in SZ patients might be related to the course of illness or to treatment variables. Prospective studies are warranted.
Language eng
DOI 10.1016/j.neulet.2007.04.001
Field of Research 0 Not Applicable
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2007, Elsevier
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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