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Role of marsupial tammar wallaby milk in lung maturation of pouch young

Modepalli,V, Hinds,LA, Sharp,JA, Lefevre,C and Nicholas,KR 2015, Role of marsupial tammar wallaby milk in lung maturation of pouch young, BMC Developmental Biology, vol. 15, no. 1, doi: 10.1186/s12861-015-0063-z.

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Title Role of marsupial tammar wallaby milk in lung maturation of pouch young
Author(s) Modepalli,V
Hinds,LA
Sharp,JAORCID iD for Sharp,JA orcid.org/0000-0002-4481-5223
Lefevre,C
Nicholas,KR
Journal name BMC Developmental Biology
Volume number 15
Issue number 1
Publisher BioMed Central Ltd.
Publication date 2015
ISSN 1471-213X
Keyword(s) Evolution
Lactation
Lung maturation
Marsupials
Milk
Preterm birth
Summary Background: Marsupials such as the tammar wallaby (M.Eugenii) have a short gestation (29.3 days) and at birth the altricial young resembles a fetus, and the major development occurs postnatally while the young remains in the mother's pouch. The essential functional factors for the maturation of the neonate are provided by the milk which changes in composition progressively throughout lactation (300 days). Morphologically the lungs of tammar pouch young are immature at birth and the majority of their development occurs during the first 100 days of lactation. Results: In this study mouse embryonic lungs (E-12) were cultured in media with tammar skim milk collected at key time points of lactation to identify factors involved in regulating postnatal lung maturation. Remarkably the embryonic lungs showed increased branching morphogenesis and this effect was restricted to milk collected at specific time points between approximately day 40 to 100 lactation. Further analysis to assess lung development showed a significant increase in the expression of marker genes Sp-C, Sp-B, Wnt-7b, BMP4 and Id2 in lung cultures incubated with milk collected at day 60. Similarly, day 60 milk specifically stimulated proliferation and elongation of lung mesenchymal cells that invaded matrigel. In addition, this milk stimulated proliferation of lung epithelium cells on matrigel, and the cells formed 3-dimensional acini with an extended lumen. Conclusions: This study has clearly demonstrated that tammar wallaby milk collected at specific times in early lactation contains bioactives that may have a significant role in lung maturation of pouch young.
Language eng
DOI 10.1186/s12861-015-0063-z
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, BioMed Central
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30072100

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.