MicroRNAs in skeletal muscle and their regulation with exercise, ageing, and disease Zacharewicz, Evelyn, Lamon, Severine and Russell, Aaron P. 2013, MicroRNAs in skeletal muscle and their regulation with exercise, ageing, and disease, Frontiers in physiology, vol. 4, Article Number : 266, pp. 1-11, doi: 10.3389/fphys.2013.00266. Attached Files Name Description MIMEType Size Downloads lamon-micrornasinskeletal-2013.pdf Published version application/pdf 932.10KB 275 Title MicroRNAs in skeletal muscle and their regulation with exercise, ageing, and disease Author(s) Zacharewicz, Evelyn Lamon, Severine orcid.org/0000-0002-3271-6551 Russell, Aaron P. orcid.org/0000-0002-7323-9501 Journal name Frontiers in physiology Volume number 4 Season Article Number : 266 Start page 1 End page 11 Total pages 11 Publisher Frontiers Place of publication Lausanne, Switzerland Publication date 2013 ISSN 1664-042X Keyword(s) ageing disease exercise miRNA skeletal muscle Science & Technology Life Sciences & Biomedicine Physiology DUCHENNE MUSCULAR-DYSTROPHY AMYOTROPHIC-LATERAL-SCLEROSIS SERUM RESPONSE FACTOR RESISTANCE EXERCISE PROTEIN-SYNTHESIS ENDURANCE EXERCISE STEM-CELLS CAENORHABDITIS-ELEGANS CIRCULATING MICRORNAS MESSENGER-RNA Summary Skeletal muscle makes up approximately 40% of the total body mass, providing structural support and enabling the body to maintain posture, to control motor movements and to store energy. It therefore plays a vital role in whole body metabolism. Skeletal muscle displays remarkable plasticity and is able to alter its size, structure and function in response to various stimuli; an essential quality for healthy living across the lifespan. Exercise is an important stimulator of extracellular and intracellular stress signals that promote positive adaptations in skeletal muscle. These adaptations are controlled by changes in gene transcription and protein translation, with many of these molecules identified as potential therapeutic targets to pharmacologically improve muscle quality in patient groups too ill to exercise. MicroRNAs (miRNAs) are recently identified regulators of numerous gene networks and pathways and mainly exert their effect by binding to their target messenger RNAs (mRNAs), resulting in mRNA degradation or preventing protein translation. The role of exercise as a regulatory stimulus of skeletal muscle miRNAs is now starting to be investigated. This review highlights our current understanding of the regulation of skeletal muscle miRNAs with exercise and disease as well as how they may control skeletal muscle health. Language eng DOI 10.3389/fphys.2013.00266 Field of Research 110602 Exercise Physiology 111699 Medical Physiology not elsewhere classified Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis) HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2013, Frontiers Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30072220 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Institute for Physical Activity and Nutrition Open Access Collection Related Links Link Description Connect to Elements publication management system Go to link with your DU access privileges   Connect to published version Go to link with your DU access privileges   Author URL Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 13 Apr 2015, 22:53:20 EST Thu, 16 Apr 2015, 05:05:18 EST Wed, 27 May 2015, 12:05:11 EST Fri, 03 Jul 2015, 06:09:06 EST Fri, 03 Jul 2015, 09:31:05 EST Fri, 03 Jul 2015, 10:08:33 EST Mon, 06 Jul 2015, 16:37:14 EST Wed, 06 Dec 2017, 06:14:06 EST Fri, 07 Sep 2018, 17:28:42 EST Filtered Full Citation counts:   Cited 69 times in TR Web of Science Cited 82 times in Scopus Search Google Scholar Access Statistics: 637 Abstract Views, 276 File Downloads  -  Detailed Statistics Created: Wed, 27 May 2015, 12:05:11 EST