N-acetyl cysteine in the treatment of obsessive compulsive and related disorders: a systematic review
Oliver, Georgina, Dean, Olivia, Camfield, David, Blair-West, Scott, Ng, Chee, Berk, Michael and Sarris, Jerome 2015, N-acetyl cysteine in the treatment of obsessive compulsive and related disorders: a systematic review, Clinical psychopharmacology and neuroscience, vol. 13, no. 1, pp. 12-24, doi: 10.9758/cpn.2015.13.1.12.
Obsessive compulsive and related disorders are a collection of debilitating psychiatric disorders in which the role of glutamate dysfunction in the underpinning neurobiology is becoming well established. N-acetyl cysteine (NAC) is a glutamate modulator with promising therapeutic effect. This paper presents a systematic review of clinical trials and case reports exploring the use of NAC for these disorders. A further objective was to detail the methodology of current clinical trials being conducted in the area.
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