Molecular insights and oligonucleotide based targeted gene therapy against cancer Subramanian, Nithya 2014, Molecular insights and oligonucleotide based targeted gene therapy against cancer, Ph.D. thesis, School of Medicine, Deakin University. Attached Files Name Description MIMEType Size Downloads subramanian-molecular-2015A.pdf Connect to thesis application/pdf 28.90MB 168 Title Molecular insights and oligonucleotide based targeted gene therapy against cancer Author Subramanian, Nithya Institution Deakin University School School of Medicine Faculty Faculty of Health Degree type Research doctorate Degree name Ph.D. Thesis advisor Kanwar Jagat orcid.org/0000-0003-3728-9568 Subramanian, Krishnakumar Kanwar (nee Kaur), Rupinder Date submitted 2014-10 Keyword(s) retinoblastoma aptamer epithelial cancer cells cancer markers cancer stem cell RB CSC Summary The thesis helps to unravel the function of T lymphoma invasion and metastasis protein (TIAM1) and nucleolin, a nucleolar protein in retinoblastoma tumorigenesis. Aptamer based targeted imaging; drug and gene delivery to retinoblastoma and epithelial cancer cells was attained. The work work finally opened up avenues for cancer stem cell targeting using aptamers, imaging of cancer cells using novel bio-orthogonal agent and use of aptamer for blocking the miRNA-17-92 cluster maturation. Language eng Field of Research 111201 Cancer Cell Biology 111204 Socio Economic Objective 920102 Cancer and Related Disorders Description of original 297 pages : illustrations ; bibliographical references Dewey Decimal Classification 571.978 Copyright notice ©The Author. All Rights Reserved Free to Read? Yes Free to Read Start Date 2016-05-01 Persistent URL http://hdl.handle.net/10536/DRO/DU:30073699 Document type: Thesis Collections: Higher degree theses (Open Access) Open Access Collection   Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Thu, 04 Jun 2015, 16:47:00 EST Mon, 08 Jun 2015, 09:07:11 EST Mon, 30 May 2016, 13:53:38 EST Mon, 30 May 2016, 13:57:01 EST Fri, 13 Jan 2017, 14:18:14 EST Thu, 09 Mar 2017, 07:11:00 EST Thu, 09 Mar 2017, 08:58:31 EST Tue, 07 Aug 2018, 10:41:48 EST Fri, 07 Sep 2018, 19:02:21 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 195 Abstract Views, 175 File Downloads  -  Detailed Statistics Created: Thu, 04 Jun 2015, 16:46:40 EST by Kate Percival