An adjunctive antidepressant nutraceutical combination in treating major depression: study protocol and clinical considerations Sarris, Jerome, Stough, Con, Bousman, Chad, Murphy, Jenifer, Savage, Karen, Smith, Deidre, Menon, Ranjit, Chamoli, Suneel, Oliver, Georgina, Berk, Michael, Byrne, Gerard, Ng, Chee and Mischoulon, David 2015, An adjunctive antidepressant nutraceutical combination in treating major depression: study protocol and clinical considerations, Advances in integrative medicine, vol. 2, no. 1, pp. 49-56, doi: 10.1016/j.aimed.2015.02.001. Attached Files Name Description MIMEType Size Downloads berk-adjunctiveantidepressant-2015.pdf Published version application/pdf 1.21MB 472 Title An adjunctive antidepressant nutraceutical combination in treating major depression: study protocol and clinical considerations Author(s) Sarris, Jerome Stough, Con Bousman, Chad Murphy, Jenifer Savage, Karen Smith, Deidre Menon, Ranjit Chamoli, Suneel Oliver, Georgina Berk, Michael orcid.org/0000-0002-5554-6946 Byrne, Gerard Ng, Chee Mischoulon, David Journal name Advances in integrative medicine Volume number 2 Issue number 1 Start page 49 End page 56 Total pages 7 Publisher Elsevier Place of publication Amsterdam, The Netherlands Publication date 2015-04 ISSN 2212-9588 2212-9596 Keyword(s) Antidepressant Depression Nutraceutical Nutrient Omega-3 Protocol RCT S-Adenosyl methionine SAMe Summary Current treatment for major depressive disorder (MDD), a prevalent and disabling mental illness, is inadequate, with two-thirds of people treated with first-line antidepressants not achieving remission. MDD is for many a chronic condition, often requiring multiple treatment attempts, thus development of additional interventions is urgently required. An emerging approach to improve non-response to antidepressants is the use of adjunctive nutraceuticals. The pathophysiology of MDD is considered to involve a range of abnormalities (monoamine impairment, neuro-endocrinological changes, reduced brain-derived neurotrophic factor, and cytokine alterations). By targeting an array of these key neurobiological pathways via specific nutraceuticals (S-adenosyl methionine; [SAMe], 5-HTP [active tryptophan], folinic acid [active folic acid], omega-3 fatty acids, and zinc), there is the potential to provide a more comprehensive therapeutic biological approach to treat depression. We are currently conducting a National Health and Medical Research Council funded study in Australia (APP1048222). The clinical trial is phase II/III, multi-site, 3-arm, 8-week, randomised, double-blind, placebo-controlled study using SAMe + folinic acid versus a combination nutraceutical (SAMe, 5-HTP, folinic acid, omega-3, and zinc) or matching placebo in 300 currently depressed participants with diagnosed MDD who are non-responsive to current antidepressants (ANZCTR, protocol number: 12613001300763). The results may provide evidence for a novel adjunctive neurobiological approach for treating depression. Language eng DOI 10.1016/j.aimed.2015.02.001 Field of Research 110319 Psychiatry (incl Psychotherapy) Socio Economic Objective 920410 Mental Health HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2015, Elsevier Free to Read? Yes Use Rights Persistent URL http://hdl.handle.net/10536/DRO/DU:30073811 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Connect to published version Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Fri, 12 Jun 2015, 16:56:30 EST Sat, 13 Jun 2015, 05:01:05 EST Mon, 15 Jun 2015, 14:32:27 EST Mon, 15 Jun 2015, 14:50:51 EST Mon, 15 Jun 2015, 15:00:48 EST Thu, 18 Jun 2015, 12:57:47 EST Fri, 19 Jun 2015, 06:12:00 EST Fri, 19 Jun 2015, 09:26:57 EST Fri, 19 Jun 2015, 09:28:14 EST Tue, 21 Jul 2015, 15:08:26 EST Tue, 21 Jul 2015, 15:13:11 EST Mon, 23 Nov 2015, 09:43:04 EST Fri, 16 Dec 2016, 11:16:34 EST Wed, 11 Jan 2017, 14:39:45 EST Fri, 21 Apr 2017, 07:09:28 EST Wed, 06 Dec 2017, 10:43:16 EST Fri, 07 Sep 2018, 17:51:56 EST Filtered Full Citation counts:   Cited 13 times in TR Web of Science Cited 13 times in Scopus Search Google Scholar Access Statistics: 669 Abstract Views, 476 File Downloads  -  Detailed Statistics Created: Fri, 12 Jun 2015, 16:56:30 EST