Increased serum levels of eotaxin/CCL11 in late-stage patients with bipolar disorder: an accelerated aging biomarker?

Panizzutti, B., Gubert, C., Schuh, A.L., Ferrari, P., Bristot, G., Fries, G.R., Massuda, R., Walz, J., Rocha, N.P., Berk, Michael, Teixeira, A.L. and Gama, C.S. 2015, Increased serum levels of eotaxin/CCL11 in late-stage patients with bipolar disorder: an accelerated aging biomarker?, Journal of affective disorders, vol. 182, pp. 64-69, doi: 10.1016/j.jad.2014.12.010.

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Title Increased serum levels of eotaxin/CCL11 in late-stage patients with bipolar disorder: an accelerated aging biomarker?
Author(s) Panizzutti, B.
Gubert, C.
Schuh, A.L.
Ferrari, P.
Bristot, G.
Fries, G.R.
Massuda, R.
Walz, J.
Rocha, N.P.
Berk, MichaelORCID iD for Berk, Michael
Teixeira, A.L.
Gama, C.S.
Journal name Journal of affective disorders
Volume number 182
Start page 64
End page 69
Total pages 6
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-08-15
ISSN 1573-2517
Keyword(s) Aging
Bipolar disorder
Summary BACKGROUND: Bipolar disorder (BD) is commonly comorbid with many medical disorders including atopy, and appears characterized by progressive social, neurobiological, and functional impairment associated with increasing number of episodes and illness duration. Early and late stages of BD may present different biological features and may therefore require different treatment strategies. Consequently, the aim of this study was to evaluate serum levels of eotaxin/CCL11, eotaxin-2/CCL24, IL-2, IL-4, IL-6, IL-10, IL-17, TNF-α, IFNγ, BDNF, TBARS, carbonyl, and GPx in a sample of euthymic patients with BD at early and late stages compared to controls. METHODS: Early-stage BD patients, 12 late-stage patients, and 25 controls matched for sex and age were selected. 10mL of peripheral blood was drawn from all subjects by venipuncture. Serum levels of BDNF, TBARS, carbonyl content, glutathione-peroxidase activity (GPx), cytokines (IL-2, IL-4, IL-6, IL-10, IL-17, TNF-α and IFNγ), and chemokines (eotaxin/CCL11 and eotaxin-2/CCL24) were measured. RESULTS: There were no demographic differences between patients and controls. No significant differences were found for any of the biomarkers, except chemokine eotaxin/CCL11, whose serum levels were higher in late-stage patients with BD when compared to controls (p=0.022; Mann-Whitney U test). LIMITATIONS: Small number of subjects and use of medication may have influenced in our results. CONCLUSION: The present study suggests a link between biomarkers of atopy and eosinophil function and bipolar disorder. These findings are also in line with progressive biological changes partially mediated by inflammatory imbalance, a process referred to as neuroprogression.
Language eng
DOI 10.1016/j.jad.2014.12.010
Field of Research 110319 Psychiatry (incl Psychotherapy)
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Elsevier
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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