Factors influencing insulin resistance in relation to atherogenicity in mood disorders, the metabolic syndrome and tobacco use disorder

Bortolasci, Chiara Cristina, Vargas, Heber Odebrecht, Vargas Nunes, Sandra Odebrecht, de Melo, Luiz Gustavo Piccoli, de Castro, Márcia Regina Pizzo, Moreira, Estefania Gastaldello, Dodd, Seetal, Barbosa, Décio Sabbatini, Berk, Michael and Maes, Michael 2015, Factors influencing insulin resistance in relation to atherogenicity in mood disorders, the metabolic syndrome and tobacco use disorder, Journal of affective disorders, vol. 179, pp. 148-155, doi: 10.1016/j.jad.2015.03.041.

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Title Factors influencing insulin resistance in relation to atherogenicity in mood disorders, the metabolic syndrome and tobacco use disorder
Author(s) Bortolasci, Chiara Cristina
Vargas, Heber Odebrecht
Vargas Nunes, Sandra Odebrecht
de Melo, Luiz Gustavo Piccoli
de Castro, Márcia Regina Pizzo
Moreira, Estefania Gastaldello
Dodd, SeetalORCID iD for Dodd, Seetal orcid.org/0000-0002-7918-4636
Barbosa, Décio Sabbatini
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Maes, Michael
Journal name Journal of affective disorders
Volume number 179
Start page 148
End page 155
Total pages 8
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015
ISSN 1573-2517
Keyword(s) Atherogenic
Bipolar disorder
Metabolic syndrome
Oxidative stress
Summary OBJECTIVE: This study examines the effects of malondialdehyde (MDA) and uric acid on insulin resistance and atherogenicity in subjects with and without mood disorders, the metabolic syndrome (MetS) and tobacco use disorder (TUD). METHODS: We included 314 subjects with depression and bipolar depression, with and without the MetS and TUD and computed insulin resistance using the updated homeostasis model assessment (HOMA2IR) and atherogenicity using the atherogenic index of plasma (AIP), that is log10 (triglycerides/high density lipoprotein (HDL) cholesterol. RESULTS: HOMA2IR is correlated with body mass index (BMI) and uric acid levels, but not with mood disorders and TUD, while the AIP is positively associated with BMI, mood disorders, TUD, uric acid, MDA and male sex. Uric acid is positively associated with insulin and triglycerides and negatively with HDL cholesterol. MDA is positively associated with triglyceride levels. Comorbid mood disorders and TUD further increase AIP but not insulin resistance. Glucose is positively associated with increasing age, male gender and BMI. DISCUSSION: The results show that mood disorders, TUD and BMI together with elevated levels of uric acid and MDA independently contribute to increased atherogenic potential, while BMI and uric acid are risk factors for insulin resistance. The findings show that mood disorders and TUD are closely related to an increased atherogenic potential but not to insulin resistance or the MetS. Increased uric acid is a highly significant risk factor for insulin resistance and increased atherogenic potential. MDA, a marker of lipid peroxidation, further contributes to different aspects of the atherogenic potential. Mood disorders and TUD increase triglyceride levels, lower HDL cholesterol and are strongly associated with the atherogenic, but not insulin resistance, component of the MetS.
Language eng
DOI 10.1016/j.jad.2015.03.041
Field of Research 110319 Psychiatry (incl Psychotherapy)
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2015
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30073841

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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