Instruments that prospectively predict bipolar disorder - a systematic review

Ratheesh, Aswin, Berk, Michael, Davey, Christopher G., McGorry, Patrick D. and Cotton, Susan M. 2015, Instruments that prospectively predict bipolar disorder - a systematic review, Journal of affective disorders, vol. 179, pp. 65-73, doi: 10.1016/j.jad.2015.03.025.

Attached Files
Name Description MIMEType Size Downloads

Title Instruments that prospectively predict bipolar disorder - a systematic review
Author(s) Ratheesh, Aswin
Berk, MichaelORCID iD for Berk, Michael
Davey, Christopher G.
McGorry, Patrick D.
Cotton, Susan M.
Journal name Journal of affective disorders
Volume number 179
Start page 65
End page 73
Total pages 9
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-07-01
ISSN 1573-2517
Keyword(s) Bipolar
Early intervention
Summary BACKGROUND: Identification of earlier stages of Bipolar Disorder (BD), even prior to the first manic episode, may help develop interventions to prevent or delay the onset of BD. However, reliable and valid instruments are necessary to ascertain such earlier stages of BD. The aim of the current review was to identify instruments that had predictive validity and utility for BD for use in early intervention (EI) settings for the prevention of BD. METHODS: We undertook a systematic examination of studies that examined participants without BD I or II at baseline and prospectively explored the predictive abilities of instruments for BD onset over a period of 6 months or more. The instruments and the studies were rated with respect to their relative validity and utility predicting onset of BD for prevention or early intervention. Odds ratios and area under the curve (AUC) values were derived when not reported. RESULTS: Six studies were included, identifying five instruments that examined sub-threshold symptoms, family history, temperament and behavioral regulation. Though none of the identified instruments had been examined in high-quality replicated studies for predicting BD, two instruments, namely the Child Behavioral Checklist - Pediatric BD phenotype (CBCL-PBD) and the General Behavioral Inventory - Revised (GBI-R), had greater levels of validity and utility. LIMITATION: Non-inclusion of studies and instruments that incidentally identified BD on follow-up limited the breadth of the review. CONCLUSION: Instruments that test domains such as subthreshold symptoms, behavioral regulation, family history, and temperament hold promise in predicting BD onset.
Language eng
DOI 10.1016/j.jad.2015.03.025
Field of Research 110319 Psychiatry (incl Psychotherapy)
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Elsevier
Persistent URL

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 8 times in TR Web of Science
Scopus Citation Count Cited 8 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 513 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Mon, 15 Jun 2015, 16:33:06 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact