Accelerated growth of preosteoblastic cells on ultrafine grained titanium

Estrin, Y., Kasper, C., Diederichs, S. and Lapovok, R. 2009, Accelerated growth of preosteoblastic cells on ultrafine grained titanium, Journal of biomedical materials research : part a, vol. 90A, no. 4, pp. 1239-1242, doi: 10.1002/jbm.a.32174.

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Title Accelerated growth of preosteoblastic cells on ultrafine grained titanium
Author(s) Estrin, Y.
Kasper, C.
Diederichs, S.
Lapovok, R.ORCID iD for Lapovok, R.
Journal name Journal of biomedical materials research : part a
Volume number 90A
Issue number 4
Start page 1239
End page 1242
Total pages 4
Publisher Wiley
Place of publication Chichester, Eng.
Publication date 2009-09-15
ISSN 1552-4965
Keyword(s) cell proliferation
preosteoblastic cells
ultra-fine grained titanium
equal channel angular pressing
MMT assay
Summary This work is part of a general effort to demonstrate the effect of the bulk microstructure of titanium as a model bone implant material on viability of osteoblasts (bone-forming cells). The objective of this work was to study the proliferation of preosteoblastic MC3T3-E1 cells extracted from mice embryos on commercial purity titanium substrates. Two distinct states of titanium were considered: as-received material with an average grain size of 4.5 microm and that processed by equal channel angular pressing (ECAP), with an average grain size of 200 nm. We report the first results of an in vitro study into the effect of this extreme grain refinement on viability and proliferation of MC3T3-E1 cells. By means of MTT assays it was demonstrated that ECAP processing of titanium enhances MC3T3-E1 culture proliferation in a spectacular way. This finding suggests that bone implants made from ECAP processed titanium may promote bone tissue growth.
Language eng
DOI 10.1002/jbm.a.32174
Field of Research 091207 Metals and Alloy Materials
060106 Cellular Interactions (incl Adhesion, Matrix, Cell Wall)
Socio Economic Objective 970109 Expanding Knowledge in Engineering
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2008, Wiley Periodicals
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