Pulsed flow chemistry : a new approach to solution handling for flow analysis coupled with chemiluminescence detection Lewis, Simon W., Francis, Paul, Lim, Kieran, Jenkins, Graeme E. and Wang, Xue D. 2000, Pulsed flow chemistry : a new approach to solution handling for flow analysis coupled with chemiluminescence detection, Analyst, vol. 125, no. 10, pp. 1869-1874. Attached Files Name Description MIMEType Size Downloads Title Pulsed flow chemistry : a new approach to solution handling for flow analysis coupled with chemiluminescence detection Author(s) Lewis, Simon W. Francis, Paul orcid.org/0000-0003-4165-6922 Lim, Kieran orcid.org/0000-0001-5355-8030 Jenkins, Graeme E. Wang, Xue D. Journal name Analyst Volume number 125 Issue number 10 Start page 1869 End page 1874 Total pages 6 Publisher Royal Society of Chemistry Place of publication London, Eng. Publication date 2000 ISSN 0003-2654 Summary Novel instrumentation for flow analysis, coupled with chemiluminescence detection, and based on pulsed flow chemistry is described. The pulsed flow chemistry manifold allows for rapid and efficient mixing of chemiluminescent reagent with sample immediately in front of the detector, thus giving high precision (less than 1 % RSD) and detectability, particularly for rapid, short-lived emissions. The instrument is also characterised by a compact size, high sampling frequency (120 to 300 samples per hour) and low reagent consumption (less than 500 ml per cycle). Other flow analysis modes (eg. flow injection, continuous flow and stopped flow) are available by simply altering software settings. The suitability of the system was shown using chemiluminescence reactions of analytical significance, namely the oxidation of luminol with hexacyanoferrate(III) in the presence of 4-hydroxy-3-methoxybenzeneacetic acid (homovanillic acid), and the reduction of acidic potassium permanganate by morphine in the presence of polyphosphates. The latter reaction was used to determine morphine in aqueous process samples and the results obtained with the pulsed flow instrument displayed good agreement (mean difference of 1.8%) with a previously validated flow injection analysis method. Language eng Field of Research 030103 Flow Analysis 0301 Analytical Chemistry 0399 Other Chemical Sciences Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences HERDC Research category C1.1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2000, The Royal Society of Chemistry Persistent URL http://hdl.handle.net/10536/DRO/DU:30076134 Document type: Journal Article Collection: School of Biological and Chemical Sciences Related Links Link Description Connect to published version Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Fri, 21 Aug 2015, 11:41:22 EST Sat, 22 Aug 2015, 05:05:11 EST Sat, 22 Aug 2015, 06:19:32 EST Wed, 11 Jan 2017, 10:06:50 EST Thu, 27 Apr 2017, 12:56:32 EST Thu, 27 Apr 2017, 12:59:05 EST Sat, 21 Oct 2017, 02:14:42 EST Filtered Full Citation counts:   Cited 49 times in TR Web of Science Cited 49 times in Scopus Search Google Scholar Access Statistics: 409 Abstract Views, 1 File Downloads  -  Detailed Statistics Created: Fri, 21 Aug 2015, 11:41:22 EST