Sarcopenia and the common mental disorders: a potential regulatory role of skeletal muscle on brain function?

Pasco, Julie A., Williams, Lana J., Jacka, Felice N., Stupka, Nicole, Brennan-Olsen, Sharon L., Holloway, Kara L. and Berk, Michael 2015, Sarcopenia and the common mental disorders: a potential regulatory role of skeletal muscle on brain function?, Current Osteoporosis Reports, vol. 13, no. 5, pp. 351-357, doi: 10.1007/s11914-015-0279-7.

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Title Sarcopenia and the common mental disorders: a potential regulatory role of skeletal muscle on brain function?
Author(s) Pasco, Julie A.ORCID iD for Pasco, Julie A.
Williams, Lana J.ORCID iD for Williams, Lana J.
Jacka, Felice N.ORCID iD for Jacka, Felice N.
Stupka, NicoleORCID iD for Stupka, Nicole
Brennan-Olsen, Sharon L.ORCID iD for Brennan-Olsen, Sharon L.
Holloway, Kara L.ORCID iD for Holloway, Kara L.
Berk, MichaelORCID iD for Berk, Michael
Journal name Current Osteoporosis Reports
Volume number 13
Issue number 5
Start page 351
End page 357
Total pages 7
Publisher Springer
Place of publication New York, N.Y.
Publication date 2015-10
ISSN 1544-2241
Keyword(s) Anxiety
Sarcopenic obesity
Summary While it is understood that body composition impacts on physical conditions, such as diabetes and cardiovascular disease, it is only now apparent that body composition might play a role in the genesis of common mental disorders, depression and anxiety. Sarcopenia occurs in ageing and comprises a progressive decline in muscle mass, strength and function, leading to frailty, decreased independence and poorer quality of life. This review presents an emerging body of evidence to support the hypothesis that shared pathophysiological pathways for sarcopenia and the common mental disorders constitute links between skeletal muscle and brain function. Contracting skeletal muscle secretes neurotrophic factors that are known to play a role in mood and anxiety, and have the dual role of nourishing neuronal growth and differentiation, while protecting the size and number of motor units in skeletal muscle. Furthermore, skeletal muscle activity has important immune and redox effects that impact behaviour and reduce muscle catabolism.
Language por
DOI 10.1007/s11914-015-0279-7
Field of Research 111714 Mental Health
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Springer
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Document type: Journal Article
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School of Medicine
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