Duration of obesity and incident hypertension in adults from the Framingham Heart Study

Tanamas, Stephanie K., Wong, Evelyn, Backholer, Kathryn, Abdullah, Asnawi, Wolfe, Rory, Barendregt, Jan and Peeters, Anna 2015, Duration of obesity and incident hypertension in adults from the Framingham Heart Study, Journal of hypertension, vol. 33, no. 3, pp. 542-545, doi: 10.1097/HJH.0000000000000441.

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Title Duration of obesity and incident hypertension in adults from the Framingham Heart Study
Author(s) Tanamas, Stephanie K.
Wong, Evelyn
Backholer, KathrynORCID iD for Backholer, Kathryn orcid.org/0000-0002-3323-575X
Abdullah, Asnawi
Wolfe, Rory
Barendregt, Jan
Peeters, AnnaORCID iD for Peeters, Anna orcid.org/0000-0003-4340-9132
Journal name Journal of hypertension
Volume number 33
Issue number 3
Start page 542
End page 545
Total pages 4
Publisher Wolters Kluwer Health
Place of publication London, Eng.
Publication date 2015-03
ISSN 0263-6352
Summary Background: Previous studies exploring the association between obesity and hypertension generally used a single baseline measurement of obesity. The effect of accumulating excess adiposity over time on the risk of hypertension is uncertain. This study aimed to examine the relationship between duration of obesity and incident hypertension using the Framingham Heart Study.

Methods: Two thousand, nine hundred and fifty-three participants aged 30–62 years without baseline hypertension were included. Blood pressure, height and weight were measured biennially. Duration of obesity was calculated. Time to incident hypertension was analysed using time-varying Cox proportional hazards regression with age as the time scale and censoring at time of death or end of follow-up.

Results: Eighty percent of participants developed hypertension (median follow-up 15.9 years). A positive association between obesity duration and incident hypertension was observed in women. There was no longer an association when time-varying BMI was adjusted for (hazard ratio 0.95; (95% confidence interval 0.85–1.05)).

Conclusion: These findings suggest that the mechanism by which excess adiposity may increase blood pressure is primarily immediate and that long-term exposure to obesity does not further increase the risk of developing hypertension beyond the level of BMI attained.
Language eng
DOI 10.1097/HJH.0000000000000441
Field of Research 111799 Public Health and Health Services not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Wolters Kluwers Health
Persistent URL http://hdl.handle.net/10536/DRO/DU:30078856

Document type: Journal Article
Collections: Faculty of Health
School of Health and Social Development
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