Regulators of mitochondrial complex I activity: a review of literature and evaluation in postmortem prefrontal cortex from patients with bipolar disorder Duong, Angela, Che, Yi, Ceylan, Deniz, Pinguelo, Arsene, Andreazza, Ana C., Young, L. Trevor and Berk, Michael 2016, Regulators of mitochondrial complex I activity: a review of literature and evaluation in postmortem prefrontal cortex from patients with bipolar disorder, Psychiatry research, vol. 236, pp. 148-157, doi: 10.1016/j.psychres.2015.12.015. Attached Files Name Description MIMEType Size Downloads Title Regulators of mitochondrial complex I activity: a review of literature and evaluation in postmortem prefrontal cortex from patients with bipolar disorder Author(s) Duong, Angela Che, Yi Ceylan, Deniz Pinguelo, Arsene Andreazza, Ana C. Young, L. Trevor Berk, Michael orcid.org/0000-0002-5554-6946 Journal name Psychiatry research Volume number 236 Start page 148 End page 157 Total pages 10 Publisher Elsevier Place of publication Amsterdam, The Netherlands Publication date 2016-02-28 ISSN 1872-7123 Keyword(s) Bipolar disorder DJ-1 Gene expression Microarray Mitochondrial complex I Mitochondrial regulators Summary Phenomenologically, bipolar disorder (BD) is characterized by biphasic increases and decreases in energy. As this is a state-related phenomenon, identifying regulators responsible for this phasic dysregulation has the potential to uncover key elements in the pathophysiology of BD. Given the evidence suggesting mitochondrial complex I dysfunction in BD, we aimed to identify the main regulators of complex I in BD by reviewing the literature and using the published microarray data to examine their gene expression profiles. We also validated protein expression levels of the main complex I regulators by immunohistochemistry. Upon reviewing the literature, we found PARK-7, STAT-3, SIRT-3 and IMP-2 play an important role in regulating complex I activity. Published microarray studies however revealed no significant direction of regulation of STAT-3, SIRT-3, and IMP-2, but a trend towards downregulation of PARK-7 was observed in BD. Immunocontent of DJ-1 (PARK-7-encoded protein) were not elevated in post mortem prefrontal cortex from patients with BD. We also found a trend towards upregulation of DJ-1 expression with age. Our results suggest that DJ-1 is not significantly altered in BD subjects, however further studies are needed to examine DJ-1 expression levels in a cohort of older patients with BD. Language eng DOI 10.1016/j.psychres.2015.12.015 Field of Research 11 Medical And Health Sciences 17 Psychology And Cognitive Sciences 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) Socio Economic Objective 920299 Health and Support Services not elsewhere classified HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2016, Elsevier Persistent URL http://hdl.handle.net/10536/DRO/DU:30080650 Document type: Journal Article Collections: Faculty of Health School of Medicine Related Links Link Description Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 11 Jan 2016, 09:43:20 EST Tue, 12 Jan 2016, 04:01:26 EST Thu, 14 Jan 2016, 05:09:27 EST Thu, 14 Apr 2016, 14:05:27 EST Mon, 18 Jul 2016, 15:54:43 EST Wed, 09 Nov 2016, 11:40:35 EST Filtered Full Citation counts:   Cited 7 times in TR Web of Science Cited 7 times in Scopus Search Google Scholar Access Statistics: 561 Abstract Views, 1 File Downloads  -  Detailed Statistics Created: Mon, 11 Jan 2016, 09:43:20 EST

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