Depression is a risk factor for incident coronary heart disease in women: an 18-year longitudinal study

O'Neil, Adrienne, Fisher, Aaron J., Kibbey, Katherine J., Jacka, Felice N., Kotowicz, Mark A., Williams, Lana J., Stuart, Amanda L., Berk, Michael, Lewandowski, Paul A., Taylor, Craig B. and Pasco, Julie A. 2016, Depression is a risk factor for incident coronary heart disease in women: an 18-year longitudinal study, Journal of affective disorders, vol. 196, pp. 117-124, doi: 10.1016/j.jad.2016.02.029.

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Title Depression is a risk factor for incident coronary heart disease in women: an 18-year longitudinal study
Author(s) O'Neil, Adrienne
Fisher, Aaron J.
Kibbey, Katherine J.
Jacka, Felice N.ORCID iD for Jacka, Felice N.
Kotowicz, Mark A.
Williams, Lana J.ORCID iD for Williams, Lana J.
Stuart, Amanda L.
Berk, MichaelORCID iD for Berk, Michael
Lewandowski, Paul A.
Taylor, Craig B.
Pasco, Julie A.
Journal name Journal of affective disorders
Volume number 196
Start page 117
End page 124
Total pages 8
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-05-15
ISSN 1573-2517
Keyword(s) Coronary heart disease
Risk factor
Summary BACKGROUND: According to a recent position paper by the American Heart Association, it remains unclear whether depression is a risk factor for incident Coronary Heart Disease (CHD). We assessed whether a depressive disorder independently predicts 18-year incident CHD in women. METHOD: A prospective longitudinal study of 860 women enrolled in the Geelong Osteoporosis Study (1993-2011) was conducted. Participants were derived from an age-stratified, representative sample of women (20-94 years) randomly selected from electoral rolls in South-Eastern Australia. The exposure was a diagnosis of a depressive disorder using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders. Outcomes data were collected from hospital medical records: (1) Primary outcome: a composite measure of cardiac death, non-fatal Myocardial Infarction or coronary intervention. (2) Secondary outcome: any cardiac event (un/stable angina, cardiac event not otherwise defined) occurring over the study period. RESULTS: Seven participants were excluded based on CHD history. Eighty-three participants (9.6%) recorded ≥1 cardiac event over the study period; 47 had a diagnosis that met criteria for inclusion in the primary analysis. Baseline depression predicted 18-year incidence, adjusting for (1) anxiety (adj. OR:2.39; 95% CIs:1.19-4.82), plus (2) typical risk factors (adj. OR:3.22; 95% CIs:1.45-6.93), plus (3) atypical risk factors (adj. OR:3.28; 95% CIs:1.36-7.90). This relationship held when including all cardiac events. No relationship was observed between depression and recurrent cardiac events. CONCLUSION: The results of this study support the contention that depression is an independent risk factor for CHD incidence in women. Moreover, the strength of association between depression and CHD incidence was of a greater magnitude than any typical and atypical risk factor.
Language eng
DOI 10.1016/j.jad.2016.02.029
Field of Research 110319 Psychiatry (incl Psychotherapy)
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
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Document type: Journal Article
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School of Medicine
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