Trajectory and predictors of quality of life in first episode psychotic mania

Oldis, Meredith, Murray, Greg, Macneil, Craig A., Hasty, Melissa K., Daglas, Rothanthi, Berk, Michael, Conus, Philippe and Cotton, Sue M. 2016, Trajectory and predictors of quality of life in first episode psychotic mania, Journal of affective disorders, vol. 195, pp. 148-155, doi: 10.1016/j.jad.2016.02.018.

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Title Trajectory and predictors of quality of life in first episode psychotic mania
Author(s) Oldis, Meredith
Murray, Greg
Macneil, Craig A.
Hasty, Melissa K.
Daglas, Rothanthi
Berk, MichaelORCID iD for Berk, Michael
Conus, Philippe
Cotton, Sue M.
Journal name Journal of affective disorders
Volume number 195
Start page 148
End page 155
Total pages 8
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-05
ISSN 1573-2517
Keyword(s) bipolar disorder
first episode
quality of life
Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences & Neurology
Summary BACKGROUND: Little is known about the trajectory of quality of life (QoL) following a first episode of psychotic mania in bipolar disorder (BD). This 18-month longitudinal study investigated the trajectory of QoL, and the influence of premorbid adjustment and symptoms on 18-month QoL in a cohort of young people experiencing a first episode of psychotic mania. METHODS: As part of an overarching clinical trial, at baseline, sixty participants presenting with a first episode of psychotic mania (BD Type 1 - DSM-IV) completed symptomatic and functional assessments in addition to the Premorbid Adjustment Scale - General Subscale. Symptom measures were repeated at 18-month follow up. QoL was rated using the Quality of Life Scale (QLS) at designated time points. RESULTS: Mean QLS scores at initial measurement (8 weeks) were 61% of the maximum possible score, increasing significantly to 70% at 12 months, and 71.2% at 18-month follow-up. Premorbid adjustment and 18-month depressive symptoms were significantly associated with QoL at 18-month follow-up. LIMITATIONS: Study limitations include the small sample size, inclusion of participants with psychotic mania only, use of measures originally designed for use with schizophrenia spectrum disorders, and lack of premorbid or baseline measurement of QoL. CONCLUSIONS: Results suggest that QoL can be maintained early in BD, and reinforce the importance of assertively treating depressive symptoms throughout the course of this disorder. The emergence of a link between premorbid adjustment and poorer QoL in this cohort highlights the importance of assessing facets of adjustment when planning psychological interventions.
Language eng
DOI 10.1016/j.jad.2016.02.018
Field of Research 110319 Psychiatry (incl Psychotherapy)
11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
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Document type: Journal Article
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School of Medicine
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