Affective instability and the course of bipolar depression: results from the STEP-BD randomised controlled trial of psychosocial treatment Stange, Jonathan P., Sylvia, Louisa G, da Silva Magalhães, Pedro Vieira, Miklowitz, David J., Otto, Michael W., Frank, Ellen, Yim, Christine, Berk, Michael, Dougherty, Darin D., Nierenberg, Andrew A. and Deckersbach, Thilo 2016, Affective instability and the course of bipolar depression: results from the STEP-BD randomised controlled trial of psychosocial treatment, British journal of psychiatry, vol. 208, no. 4, pp. 352-358, doi: 10.1192/bjp.bp.114.162073. Attached Files Name Description MIMEType Size Downloads Title Affective instability and the course of bipolar depression: results from the STEP-BD randomised controlled trial of psychosocial treatment Author(s) Stange, Jonathan P. Sylvia, Louisa G da Silva Magalhães, Pedro Vieira Miklowitz, David J. Otto, Michael W. Frank, Ellen Yim, Christine Berk, Michael orcid.org/0000-0002-5554-6946 Dougherty, Darin D. Nierenberg, Andrew A. Deckersbach, Thilo Journal name British journal of psychiatry Volume number 208 Issue number 4 Start page 352 End page 358 Total pages 9 Publisher Royal College of Psychiatrists Place of publication London, Eng. Publication date 2016-04 ISSN 1472-1465 Summary BACKGROUND: Little is known about predictors of recovery from bipolar depression. AIMS: We investigated affective instability (a pattern of frequent and large mood shifts over time) as a predictor of recovery from episodes of bipolar depression and as a moderator of response to psychosocial treatment for acute depression. METHOD: A total of 252 out-patients with DSM-IV bipolar I or II disorder and who were depressed enrolled in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) and were randomised to one of three types of intensive psychotherapy for depression (n = 141) or a brief psychoeducational intervention (n = 111). All analyses were by intention-to-treat. RESULTS: Degree of instability of symptoms of depression and mania predicted a lower likelihood of recovery and longer time until recovery, independent of the concurrent effects of symptom severity. Affective instability did not moderate the effects of psychosocial treatment on recovery from depression. CONCLUSIONS: Affective instability may be a clinically relevant characteristic that influences the course of bipolar depression. Language eng DOI 10.1192/bjp.bp.114.162073 Field of Research 110319 Psychiatry (incl Psychotherapy) 11 Medical And Health Sciences 17 Psychology And Cognitive Sciences Socio Economic Objective 920410 Mental Health HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2016, Royal College of Psychiatrists Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30082047 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Link to full-text (open access)   Connect to published version Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Wed, 09 Mar 2016, 13:15:00 EST Thu, 10 Mar 2016, 04:01:28 EST Thu, 17 Mar 2016, 05:11:10 EST Thu, 14 Apr 2016, 14:20:08 EST Thu, 14 Apr 2016, 14:24:53 EST Mon, 18 Jul 2016, 16:02:13 EST Wed, 09 Nov 2016, 11:41:47 EST Sun, 10 Nov 2019, 22:39:50 EST Filtered Full Citation counts:   Cited 17 times in TR Web of Science Cited 17 times in Scopus Search Google Scholar Access Statistics: 597 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Wed, 09 Mar 2016, 13:15:00 EST