Aligned nanofibers from polypyrrole/graphene as electrodes for regeneration of optic nerve via electrical stimulation

Yan, Lu, Zhao, Bingxin, Liu, Xiaohong, Li, Xuan, Zeng, Chao, Shi, Haiyan, Xu, Xiaoxue, Lin, Tong, Dai, Liming and Liu, Yong 2016, Aligned nanofibers from polypyrrole/graphene as electrodes for regeneration of optic nerve via electrical stimulation, ACS Applied materials and interfaces, vol. 8, no. 11, pp. 6834-6840.

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Title Aligned nanofibers from polypyrrole/graphene as electrodes for regeneration of optic nerve via electrical stimulation
Author(s) Yan, Lu
Zhao, Bingxin
Liu, Xiaohong
Li, Xuan
Zeng, Chao
Shi, Haiyan
Xu, Xiaoxue
Lin, TongORCID iD for Lin, Tong
Dai, Liming
Liu, Yong
Journal name ACS Applied materials and interfaces
Volume number 8
Issue number 11
Start page 6834
End page 6840
Total pages 7
Publisher American Chemical Society
Place of publication Washington, D.C.
Publication date 2016-02-29
ISSN 1944-8252
Keyword(s) polypyrrole
retina ganglion cells
electrical stimulation
optical nerve regeneration
Summary The damage of optic nerve will cause permanent visual field loss and irreversible ocular diseases, such as glaucoma. The damage of optic nerve is mainly derived from the atrophy, apoptosis or death of retinal ganglion cells (RGCs). Though some progress has been achieved on electronic retinal implants that can electrically stimulate undamaged parts of RGCs or retina to transfer signals, stimulated self-repair/regeneration of RGCs has not been realized yet. The key challenge for development of electrically stimulated regeneration of RGCs is the selection of stimulation electrodes with a sufficient safe charge injection limit (Q(inj), i.e., electrochemical capacitance). Most traditional electrodes tend to have low Q(inj) values. Herein, we synthesized polypyrrole functionalized graphene (PPy-G) via a facile but efficient polymerization-enhanced ball milling method for the first time. This technique could not only efficiently introduce electron-acceptor nitrogen to enhance capacitance, but also remain a conductive platform-the π-π conjugated carbon plane for charge transportation. PPy-G based aligned nanofibers were subsequently fabricated for guided growth and electrical stimulation (ES) of RGCs. Significantly enhanced viability, neurite outgrowth and antiaging ability of RGCs were observed after ES, suggesting possibilities for regeneration of optic nerve via ES on the suitable nanoelectrodes.
Language eng
Field of Research 091205 Functional Materials
091209 Polymers and Plastics
090301 Biomaterials
Socio Economic Objective 860406 Synthetic Fibres
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, American Chemical Society
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Collections: Institute for Frontier Materials
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