Development and evaluation of a novel insulin analogue Khedkar, Anand 2015, Development and evaluation of a novel insulin analogue, PhD thesis, School of Life and Environmental Sciences, Deakin University. Attached Files Name Description MIMEType Size Downloads khedkar-developmentand-2015A.pdf Connect to thesis application/pdf 6.43MB 165 Title Development and evaluation of a novel insulin analogue Author Khedkar, Anand Institution Deakin University School School of Life and Environmental Sciences Faculty Faculty of Science, Engineering and Built Environment Degree type Research doctorate Degree name PhD Thesis advisor Barrow, Colin orcid.org/0000-0002-2153-7267 Sastry, Kedarnath Date submitted 2015-02 Keyword(s) diabetes insulin delivery oral delivery Summary  This project examined the impact of pegylation on secondary structure of insulin during tablet making process and assessed the metabolism in in-vitro and in-vivo model. It was found that pegylation per se does not affect the secondary structure of insulin. The tablet making process did not have any impact on the pegylated insulin structure. In the in vitro model and in vivo model, pegylated lysine and free peg molecule were found to be the metabolites specific to pegylated insulin. Language eng Field of Research 100306 Industrial Molecular Engineering of Nucleic Acids and Proteins 100403 Medical Molecular Engineering of Nucleic Acids and Proteins Socio Economic Objective 920104 Diabetes Description of original 201 pages : illustrations, tables, graphs, some coloured Dewey Decimal Classification 616.46206 Copyright notice ©The author Free to Read? Yes Free to Read Start Date 2017-05-19 Persistent URL http://hdl.handle.net/10536/DRO/DU:30082751 Document type: Thesis Collections: Higher degree theses (Open Access) Open Access Collection   Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Tue, 12 Apr 2016, 10:14:04 EST Wed, 13 Apr 2016, 08:38:34 EST Fri, 10 Jun 2016, 11:27:36 EST Fri, 10 Jun 2016, 11:30:50 EST Fri, 10 Jun 2016, 11:32:14 EST Fri, 10 Jun 2016, 11:33:15 EST Thu, 09 Mar 2017, 09:12:26 EST Fri, 19 May 2017, 09:37:07 EST Thu, 09 Aug 2018, 11:13:49 EST Fri, 07 Sep 2018, 19:10:20 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 145 Abstract Views, 172 File Downloads  -  Detailed Statistics Created: Tue, 12 Apr 2016, 10:13:49 EST by Kate Percival