Associations between FTO genotype and total energy and macronutrient intake in adults: a systematic review and meta-analysis

Livingstone, Katherine M., Celis-Morales, C., Lara, J., Ashor, A.W., Lovegrove, J. A., Martinez, J.A., Saris, W. H., Gibney, M., Manios, Y., Traczyk, I., Drevon, C. A., Daniel, H., Gibney, E. R., Brennan, L., Bouwman, J., Grimaldi, K. A. and Mathers, J.C. 2015, Associations between FTO genotype and total energy and macronutrient intake in adults: a systematic review and meta-analysis, Obesity reviews, vol. 16, no. 8, pp. 666-678, doi: 10.1111/obr.12290.

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Title Associations between FTO genotype and total energy and macronutrient intake in adults: a systematic review and meta-analysis
Author(s) Livingstone, Katherine M.ORCID iD for Livingstone, Katherine M.
Celis-Morales, C.
Lara, J.
Ashor, A.W.
Lovegrove, J. A.
Martinez, J.A.
Saris, W. H.
Gibney, M.
Manios, Y.
Traczyk, I.
Drevon, C. A.
Daniel, H.
Gibney, E. R.
Brennan, L.
Bouwman, J.
Grimaldi, K. A.
Mathers, J.C.
Journal name Obesity reviews
Volume number 16
Issue number 8
Start page 666
End page 678
Total pages 13
Publisher Wiley
Place of publication London, Eng.
Publication date 2015-08
ISSN 1467-789X
Keyword(s) FTO
macronutrient intake
total energy intake
Summary Risk variants of fat mass and obesity-associated (FTO) gene have been associated with increased obesity. However, the evidence for associations between FTO genotype and macronutrient intake has not been reviewed systematically. Our aim was to evaluate the potential associations between FTO genotype and intakes of total energy, fat, carbohydrate and protein. We undertook a systematic literature search in OVID MEDLINE, Scopus, EMBASE and Cochrane of associations between macronutrient intake and FTO genotype in adults. Beta coefficients and confidence intervals (CIs) were used for per allele comparisons. Random-effect models assessed the pooled effect sizes. We identified 56 eligible studies reporting on 213,173 adults. For each copy of the FTO risk allele, individuals reported 6.46 kcal day(-1) (95% CI: 10.76, 2.16) lower total energy intake (P = 0.003). Total fat (P = 0.028) and protein (P = 0.006), but not carbohydrate intakes, were higher in those carrying the FTO risk allele. After adjustment for body weight, total energy intakes remained significantly lower in individuals with the FTO risk genotype (P = 0.028). The FTO risk allele is associated with a lower reported total energy intake and with altered patterns of macronutrient intake. Although significant, these differences are small and further research is needed to determine whether the associations are independent of dietary misreporting.
Notes Authors also on behalf of Food4Me
Language eng
DOI 10.1111/obr.12290
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
Socio Economic Objective 920411 Nutrition
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, World Obesity
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Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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