Cancer and life-history traits: lessons from host-parasite interactions

Ujvari, Beata, Beckmann, Christa, Biro, Peter A., Arnal, Audrey, Tasiemski, Aurelie, Massol, Francois, Salzet, Michel, Mery, Frederic, Boidin-Wichlacz, Celine, Misse, Dorothee, Renaud, Francois, Vittecoq, Marion, Tissot, Tazzio, Roche, Benjamin, Poulin, Robert and Thomas, Frederic 2016, Cancer and life-history traits: lessons from host-parasite interactions, Parasitology, vol. 143, no. 5, pp. 533-541, doi: 10.1017/S0031182016000147.

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Title Cancer and life-history traits: lessons from host-parasite interactions
Author(s) Ujvari, BeataORCID iD for Ujvari, Beata
Beckmann, ChristaORCID iD for Beckmann, Christa
Biro, Peter A.ORCID iD for Biro, Peter A.
Arnal, Audrey
Tasiemski, Aurelie
Massol, Francois
Salzet, Michel
Mery, Frederic
Boidin-Wichlacz, Celine
Misse, Dorothee
Renaud, Francois
Vittecoq, Marion
Tissot, Tazzio
Roche, Benjamin
Poulin, Robert
Thomas, Frederic
Journal name Parasitology
Volume number 143
Issue number 5
Start page 533
End page 541
Total pages 9
Publisher Cambridge University Press
Place of publication Cambridge, Eng.
Publication date 2016-04
ISSN 0031-1820
Keyword(s) cancer
evolutionary ecology
life-history traits
Science & Technology
Life Sciences & Biomedicine
Summary Despite important differences between infectious diseases and cancers, tumour development (neoplasia) can nonetheless be closely compared to infectious disease because of the similarity of their effects on the body. On this basis, we predict that many of the life-history (LH) responses observed in the context of host-parasite interactions should also be relevant in the context of cancer. Parasites are thought to affect LH traits of their hosts because of strong selective pressures like direct and indirect mortality effects favouring, for example, early maturation and reproduction. Cancer can similarly also affect LH traits by imposing direct costs and/or indirectly by triggering plastic adjustments and evolutionary responses. Here, we discuss how and why a LH focus is a potentially productive but under-exploited research direction for cancer research, by focusing our attention on similarities between infectious disease and cancer with respect to their effects on LH traits and their evolution. We raise the possibility that LH adjustments can occur in response to cancer via maternal/paternal effects and that these changes can be heritable to (adaptively) modify the LH traits of their offspring. We conclude that LH adjustments can potentially influence the transgenerational persistence of inherited oncogenic mutations in populations.
Language eng
DOI 10.1017/S0031182016000147
Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified
060806 Animal Physiological Ecology
0707 Veterinary Sciences
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Cambridge University Press
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