Associations between DNA damage, DNA base excision repair gene variability and Alzheimer's disease risk Kwiatkowski, Dominik, Czarny, Piotr, Toma, Monika, Jurkowska, Natalia, Sliwinska, Agnieszka, Drzewoski, Jozef, Bachurska, Agnieszka, Szemraj, Janusz, Maes, Michael, Berk, Michael, Su, Kuan-Pin, Galecki, Piotr and Sliwinski, Tomasz 2016, Associations between DNA damage, DNA base excision repair gene variability and Alzheimer's disease risk, Dementia and geriatric cognitive disorders, vol. 41, no. 3-4, pp. 152-171, doi: 10.1159/000443953. Attached Files Name Description MIMEType Size Downloads Title Associations between DNA damage, DNA base excision repair gene variability and Alzheimer's disease risk Author(s) Kwiatkowski, Dominik Czarny, Piotr Toma, Monika Jurkowska, Natalia Sliwinska, Agnieszka Drzewoski, Jozef Bachurska, Agnieszka Szemraj, Janusz Maes, Michael Berk, Michael orcid.org/0000-0002-5554-6946 Su, Kuan-Pin Galecki, Piotr Sliwinski, Tomasz Journal name Dementia and geriatric cognitive disorders Volume number 41 Issue number 3-4 Start page 152 End page 171 Total pages 20 Publisher Karger Place of publication Basel, Switzerland Publication date 2016 ISSN 1421-9824 Keyword(s) DNA damage DNA base excision repair Alzheimer’s disease risk Dementia Oxidative stress Science & Technology Life Sciences & Biomedicine Geriatrics & Gerontology Clinical Neurology Psychiatry Neurosciences & Neurology Alzheimer's disease risk AMYLOID PRECURSOR PROTEIN LUNG-CANCER RISK MITOCHONDRIAL-DNA POLYMERASE-BETA POLYMORPHISMS XRCC1 BRAIN LYMPHOCYTES PRODUCTS Summary BACKGROUND: Increased oxidative damage to DNA is one of the pathways involved in Alzheimer's disease (AD). Insufficient base excision repair (BER) is in part responsible for increased oxidative DNA damage. The aim of the present study was to assess the effect of polymorphic variants of BER-involved genes and the peripheral markers of DNA damage and repair in patients with AD. MATERIAL AND METHODS: Comet assays and TaqMan probes were used to assess DNA damage, BER efxFB01;ciency and polymorphic variants of 12 BER genes in blood samples from 105 AD patients and 130 controls. The DNA repair efficacy (DRE) was calculated according to a specific equation. RESULTS: The levels of endogenous and oxidative DNA damages were higher in AD patients than controls. The polymorphic variants of XRCC1 c.580C>T XRCC1 c.1196A>G and OGG1 c.977C>G are associated with increased DNA damage in AD. CONCLUSION: Our results show that oxidative stress and disturbances in DRE are particularly responsible for the elevated DNA lesions in AD. The results suggest that oxidative stress and disruption in DNA repair may contribute to increased DNA damage in AD patients and risk of this disease. In addition, disturbances in DRE may be associated with polymorphisms of OGG1 and XRCC1. Language eng DOI 10.1159/000443953 Field of Research 110319 Psychiatry (incl Psychotherapy) 1103 Clinical Sciences 1702 Cognitive Science 1109 Neurosciences Socio Economic Objective 920410 Mental Health HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2016, S. Karger AG Persistent URL http://hdl.handle.net/10536/DRO/DU:30083774 Document type: Journal Article Collections: Faculty of Health School of Medicine Related Links Link Description Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Fri, 27 May 2016, 18:46:22 EST Sat, 28 May 2016, 05:00:32 EST Mon, 30 May 2016, 08:41:29 EST Fri, 17 Jun 2016, 06:10:41 EST Mon, 18 Jul 2016, 16:07:59 EST Thu, 25 Aug 2016, 10:41:57 EST Thu, 25 Aug 2016, 10:52:21 EST Thu, 25 Aug 2016, 11:56:44 EST Filtered Full Citation counts:   Cited 14 times in TR Web of Science Cited 13 times in Scopus Search Google Scholar Access Statistics: 472 Abstract Views, 3 File Downloads  -  Detailed Statistics Created: Fri, 27 May 2016, 18:46:22 EST

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