Silk fibroin as a water-soluble bio-resist and its thermal properties

Morikawa, Junko, Ryu, Meguya, Maximova, Ksenia, Balčytis, Armandas, Seniutinas, Gediminas, Fan, Linpeng, Mizeikis, Vygantas, Li, Jingliang, Wang, Xuewen, Zamengo, Massimiliano, Wang, Xungai and Juodkazis, Saulius 2016, Silk fibroin as a water-soluble bio-resist and its thermal properties, RSC advances, vol. 6, no. 14, pp. 11863-11869, doi: 10.1039/c5ra20201a.

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Title Silk fibroin as a water-soluble bio-resist and its thermal properties
Author(s) Morikawa, Junko
Ryu, Meguya
Maximova, Ksenia
Balčytis, Armandas
Seniutinas, Gediminas
Fan, Linpeng
Mizeikis, Vygantas
Li, JingliangORCID iD for Li, Jingliang
Wang, Xuewen
Zamengo, Massimiliano
Wang, XungaiORCID iD for Wang, Xungai
Juodkazis, Saulius
Journal name RSC advances
Volume number 6
Issue number 14
Start page 11863
End page 11869
Total pages 7
Publisher Royal Society of Chemistry
Place of publication Cambridge, Eng.
Publication date 2016
ISSN 2046-2069
Keyword(s) Amides
Electron beam lithography
Infrared imaging
Direct contact method
Laser treatment
Protein crystallization
Silk fibroin films
Spectral change
Spectral signature
Stretching bands
Surface functionalization
Summary Thermal diffusivity of silk fibroin films, α = (1.6 ± 0.24) × 10-7 m2 s-1, was measured by a direct contact method. It was shown to be reduced down to ∼1 × 10-7 m2 s-1 in the crystallized phase, consistent with the multi-domain composition of β-sheet assemblies. Crystalline silk with β-sheets was made by dipping into alcohol and was used as a positive electron beam lithography (EBL) resist. It is shown by direct IR imaging of the 1619 cm-1 amide-I CO spectral signature and 3290 cm-1 amide-A N-H stretching band that an e-beam is responsible for unzipping β-sheets, which subsequently results in exposed areas returning to a water soluble state. This makes it possible to develop a water-based biocompatible silk resist and use it in lithography applications. The general principles of protein crystallization, traceable to spectral changes in IR amide bands of silk, can be used as a guide for the creation of new protein EBL resists and to quantify the electron dose required for solubility. Foam formation and laser treatments of silk can provide new approaches in surface functionalization and fabrication of 3D bio-scaffolds.
Language eng
DOI 10.1039/c5ra20201a
Field of Research 091205 Functional Materials
Socio Economic Objective 970109 Expanding Knowledge in Engineering
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Royal Society of Chemistry
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