The application of aptamers for immunohistochemistry

Bauer, Michelle, Macdonald, Joanna, Henri, Justin, Duan, Wei and Shigdar, Sarah 2016, The application of aptamers for immunohistochemistry, Nucleic acid therapeutics, vol. 26, no. 3, pp. 120-126, doi: 10.1089/nat.2015.0569.

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Title The application of aptamers for immunohistochemistry
Author(s) Bauer, Michelle
Macdonald, Joanna
Henri, Justin
Duan, WeiORCID iD for Duan, Wei
Shigdar, SarahORCID iD for Shigdar, Sarah
Journal name Nucleic acid therapeutics
Volume number 26
Issue number 3
Start page 120
End page 126
Total pages 7
Publisher Mary Ann Liebert Inc., Publishers
Place of publication New Rochelle, N.Y.
Publication date 2016-06-03
ISSN 2159-3345
Summary Immunohistochemistry has helped to make surgical pathology the "gold" standard for tumor diagnosis. However, given the numerous problems associated with the use of antibodies for the staining of cellular markers in paraffin-embedded tissues, there is a requirement for novel agents that have the advantages of antibodies, but with few of the disadvantages. Aptamers, which are chemical antibodies, are highly specific and sensitive, like their protein counterparts, but display few of the disadvantages. These molecules represent a unique reagent that has the potential to revolutionize the field of histopathological diagnostics. In this study, we present a review of some of the aptamers that have been validated for use in diagnoses and suggest some of the advantages to using these molecules in the future.
Language eng
DOI 10.1089/nat.2015.0569
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Mary Ann Liebert Inc., Publishers
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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