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The Drosophila melanogaster Genetic Reference Panel

Mackay, Trudy FC, Richards, Stephen, Stone, Eric A, Barbadilla, Antonio, Ayroles, Julien F, Zhu, Dianhui, Casillas, Sonia, Han, Yi, Magwire, Michael M, Cridland, Julie M, Richardson, Mark F, Anholt, Robert RH, Barrón, Maite, Bess, Crystal, Blankenburg, Kerstin Petra, Carbone, Mary Anna, Castellano, David, Chaboub, Lesley, Duncan, Laura, Harris, Zeke, Javaid, Mehwish, Jayaseelan, Joy Christina, Jhangiani, Shalini N, Jordan, Katherine W, Lara, Fremiet, Lawrence, Faye, Lee, Sandra L, Librado, Pablo, Linheiro, Raquel S, Lyman, Richard F, Mackey, Aaron J, Munidasa, Mala, Muzny, Donna Marie, Nazareth, Lynne, Newsham, Irene, Perales, Lora, Pu, Ling-Ling, Qu, Carson, Ràmia, Miquel, Reid, Jeffrey G, Rollmann, Stephanie M, Rozas, Julio, Saada, Nehad, Turlapati, Lavanya, Worley, Kim C, Wu, Yuan-Qing, Yamamoto, Akihiko, Zhu, Yiming, Bergman, Casey M, Thornton, Kevin R, Mittelman, David and Gibbs, Richard A 2012, The Drosophila melanogaster Genetic Reference Panel, Nature, vol. 482, no. 7384, pp. 173-178, doi: 10.1038/nature10811.

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Title The Drosophila melanogaster Genetic Reference Panel
Formatted title The Drosophila melanogaster Genetic Reference Panel
Author(s) Mackay, Trudy FC
Richards, Stephen
Stone, Eric A
Barbadilla, Antonio
Ayroles, Julien F
Zhu, Dianhui
Casillas, Sonia
Han, Yi
Magwire, Michael M
Cridland, Julie M
Richardson, Mark FORCID iD for Richardson, Mark F
Anholt, Robert RH
Barrón, Maite
Bess, Crystal
Blankenburg, Kerstin Petra
Carbone, Mary Anna
Castellano, David
Chaboub, Lesley
Duncan, Laura
Harris, Zeke
Javaid, Mehwish
Jayaseelan, Joy Christina
Jhangiani, Shalini N
Jordan, Katherine W
Lara, Fremiet
Lawrence, Faye
Lee, Sandra L
Librado, Pablo
Linheiro, Raquel S
Lyman, Richard F
Mackey, Aaron J
Munidasa, Mala
Muzny, Donna Marie
Nazareth, Lynne
Newsham, Irene
Perales, Lora
Pu, Ling-Ling
Qu, Carson
Ràmia, Miquel
Reid, Jeffrey G
Rollmann, Stephanie M
Rozas, Julio
Saada, Nehad
Turlapati, Lavanya
Worley, Kim C
Wu, Yuan-Qing
Yamamoto, Akihiko
Zhu, Yiming
Bergman, Casey M
Thornton, Kevin R
Mittelman, David
Gibbs, Richard A
Journal name Nature
Volume number 482
Issue number 7384
Start page 173
End page 178
Total pages 6
Publisher Nature Publishing Group
Place of publication London, Eng.
Publication date 2012-02-09
ISSN 1476-4687
Keyword(s) Alleles
Chromosomes, Insect
Drosophila melanogaster
Genome-Wide Association Study
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Selection, Genetic
X Chromosome
Summary A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype–phenotype map were based on incomplete genotypic information. Here, we describe the Drosophila melanogaster Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the X chromosome, evidence for positive and negative selection, and rapid evolution of the X chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype–phenotype mapping using the power of Drosophila genetics.
Language eng
DOI 10.1038/nature10811
Field of Research 060408 Genomics
MD Multidisciplinary
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2012, Macmillan Publishers Limited
Free to Read? Yes
Use Rights Creative Commons Attribution Non-Commercial Share Alike licence
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact