Intrinsic versus extrinsic cancer risks: the debate continues

Thomas, Frederic, Roche, Benjamin and Ujvari, Beata 2016, Intrinsic versus extrinsic cancer risks: the debate continues, Trends in cancer, vol. 2, no. 2, pp. 68-69, doi: 10.1016/j.trecan.2016.01.004.

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Title Intrinsic versus extrinsic cancer risks: the debate continues
Author(s) Thomas, Frederic
Roche, Benjamin
Ujvari, BeataORCID iD for Ujvari, Beata
Journal name Trends in cancer
Volume number 2
Issue number 2
Start page 68
End page 69
Total pages 2
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-02-01
ISSN 2405-8033
Summary Deciphering the relative contribution of intrinsic (e.g., genetic) and extrinsic (e.g., life style, environmental) risk factors in cancer development is crucial for strategizing cancer prevention. The recent publication by Wu and colleagues in Nature appears as an important contribution to the debate previously initiated by Tomasetti and Vogelstein in Science, who proposed that two-thirds of cancers can be attributed to random mutations and hence 'bad luck'. By contrast, Wu and colleagues, using four lines of evidence, suggest that cancer risk is dominated by extrinsic factors, and intrinsic risk factors only contribute marginally. The debate remains open, and an approach focusing on the evolutionary ecology of organs could provide crucial insights.
Language eng
DOI 10.1016/j.trecan.2016.01.004
Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified
119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
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Created: Mon, 28 Nov 2016, 14:34:46 EST

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