Past physical activity and age-related macular degeneration: the Melbourne Collaborative Cohort Study

McGuinness, Myra B., Karahalios, Amalia, Simpson, Julie A., Guymer, Robyn H., Robman, Luba D., Hodge, Allison M., Cerin, Ester, Giles, Graham G. and Finger, Robert P. 2016, Past physical activity and age-related macular degeneration: the Melbourne Collaborative Cohort Study, British journal of ophthalmology, vol. 100, no. 10, pp. 1353-1358, doi: 10.1136/bjophthalmol-2015-307663.

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Title Past physical activity and age-related macular degeneration: the Melbourne Collaborative Cohort Study
Author(s) McGuinness, Myra B.
Karahalios, Amalia
Simpson, Julie A.
Guymer, Robyn H.
Robman, Luba D.
Hodge, Allison M.
Cerin, Ester
Giles, Graham G.
Finger, Robert P.
Journal name British journal of ophthalmology
Volume number 100
Issue number 10
Start page 1353
End page 1358
Total pages 7
Publisher BMJ
Place of publication London, Eng.
Publication date 2016-10
ISSN 1468-2079
Keyword(s) Epidemiology
Macula
Neovascularisation
Retina
Summary BACKGROUND/AIMS: To assess the association between past physical activity and early, intermediate and late age-related macular degeneration (AMD) in a community-based cohort study in Melbourne, Australia.

METHODS: Diet and lifestyle information was recorded at baseline (1990-1994) and total recreational activity was derived from walking, vigorous and non-vigorous exercise. At follow-up (2003-2007), digital macular photographs were graded for early, intermediate and late AMD. Data were analysed using multinomial logistic regression controlling for age, sex, smoking, region of descent, diet and alcohol. Effect modification by sex was investigated.

RESULTS: Out of 20 816 participants, early, intermediate and late AMD were detected at follow-up in 4244 (21%), 2661 (13%) and 122 (0.6%) participants, respectively. No association was detected between past total recreational physical activity and early, intermediate or late AMD. Frequent (≥3 times/week) and less frequent (1-2 times/week) vigorous exercise were associated with lower odds of intermediate and late AMD in univariable models. After controlling for confounders, there was evidence of effect modification by sex and frequent vigorous exercise was associated with a 22% decrease in the odds of intermediate AMD (95% CI 4% to 36%) in women, but no association was found for men.

CONCLUSIONS: Past frequent vigorous exercise may be inversely related to the presence of intermediate AMD in women. Further studies are needed to confirm whether physical activity and exercise have a protective effect for AMD.
Language eng
DOI 10.1136/bjophthalmol-2015-307663
Field of Research 111399 Ophthalmology and Optometry not elsewhere classified
1103 Clinical Sciences
1113 Ophthalmology And Optometry
1117 Public Health And Health Services
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, BMJ
Persistent URL http://hdl.handle.net/10536/DRO/DU:30086752

Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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