Elucidating the mechanisms of nanodiamond-promoted structural disruption of crystallised lipid

Hughes, Zak E. and Walsh, Tiffany R. 2016, Elucidating the mechanisms of nanodiamond-promoted structural disruption of crystallised lipid, Soft matter, vol. 12, no. 40, pp. 8338-8347, doi: 10.1039/c6sm01155a.

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Title Elucidating the mechanisms of nanodiamond-promoted structural disruption of crystallised lipid
Author(s) Hughes, Zak E.ORCID iD for Hughes, Zak E. orcid.org/0000-0003-2166-9822
Walsh, Tiffany R.ORCID iD for Walsh, Tiffany R. orcid.org/0000-0002-0233-9484
Journal name Soft matter
Volume number 12
Issue number 40
Start page 8338
End page 8347
Total pages 10
Publisher Royal Society of Chemistry
Place of publication London, Eng.
Publication date 2016-10
ISSN 1744-6848
Keyword(s) Science & Technology
Physical Sciences
Chemistry, Physical
Materials Science, Multidisciplinary
Physics, Multidisciplinary
Polymer Science
Materials Science
Summary The removal or structural disruption of crystallised lipid is a pivotal but energy-intensive step in a wide range of industrial and biological processes. Strategies to disrupt the structure of crystallised lipid in aqueous solution at lower temperatures are much needed, where nanoparticle-based strategies show enormous promise. Using the aqueous tristearin bilayer as a model for crystallised lipid, we demonstrate that the synergistic use of surfactant and detonation nanodiamonds can depress the onset temperature at which disruption of the crystallised lipid structure occurs. Our simulations reveal the molecular-scale mechanisms by which this disruption takes place, indicating that the nanodiamonds serve a dual purpose. First, the nanodiamonds are predicted to facilitate delivery of surfactant to the lipid/water interface, and second, nanodiamond adsorption acts to roughen the lipid/water interface, enhancing ingress of surfactant into the bilayer. We find the balance of the hydrophobic surface area of the nanodiamond and the nanodiamond surface charge density to be a key determinant of the effectiveness of using nanodiamonds to facilitate lipid disruption. For the nanodiamond size considered here, we identify a moderate surface charge density, that ensures the nanodiamonds are neither too hydrophobic nor too hydrophilic, to be optimal.
Language eng
DOI 10.1039/c6sm01155a
Field of Research 100701 Environmental Nanotechnology
100708 Nanomaterials
030603 Colloid and Surface Chemistry
030402 Biomolecular Modelling and Design
030704 Statistical Mechanics in Chemistry
Socio Economic Objective 970109 Expanding Knowledge in Engineering
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Royal Society of Chemistry
Persistent URL http://hdl.handle.net/10536/DRO/DU:30086981

Document type: Journal Article
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