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Quantifying the association between physical activity and cardiovascular disease and diabetes: a systematic review and meta-analysis

Wahid, Ahad, Manek, Nishma, Nichols, Melanie, Kelly, Paul, Foster, Charlie, Webster, Premila, Kaur, Asha, Friedemann Smith, Claire, Wilkins, Elizabeth, Rayner, Mike, Roberts, Nia and Scarborough, Peter 2016, Quantifying the association between physical activity and cardiovascular disease and diabetes: a systematic review and meta-analysis, Journal of the American Heart Association, vol. 5, no. 9, Article number: e002495, pp. 1-11, doi: 10.1161/JAHA.115.002495.

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Title Quantifying the association between physical activity and cardiovascular disease and diabetes: a systematic review and meta-analysis
Author(s) Wahid, Ahad
Manek, Nishma
Nichols, MelanieORCID iD for Nichols, Melanie orcid.org/0000-0002-7834-5899
Kelly, Paul
Foster, Charlie
Webster, Premila
Kaur, Asha
Friedemann Smith, Claire
Wilkins, Elizabeth
Rayner, Mike
Roberts, Nia
Scarborough, Peter
Journal name Journal of the American Heart Association
Volume number 5
Issue number 9
Season Article number: e002495
Start page 1
End page 11
Total pages 11
Publisher Wiley-Blackwell Publishing
Place of publication Hoboken, N.J.
Publication date 2016-09
ISSN 2047-9980
Keyword(s) cardiovascular diseases
meta‐analysis
physical activity
systematic review
Summary BACKGROUND: The relationships between physical activity (PA) and both cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) have predominantly been estimated using categorical measures of PA, masking the shape of the dose-response relationship. In this systematic review and meta-analysis, for the very first time we are able to derive a single continuous PA metric to compare the association between PA and CVD/T2DM, both before and after adjustment for a measure of body weight.

METHODS AND RESULTS: The search was applied to MEDLINE and EMBASE electronic databases for all studies published from January 1981 to March 2014. A total of 36 studies (3 439 874 participants and 179 393 events, during an average follow-up period of 12.3 years) were included in the analysis (33 pertaining to CVD and 3 to T2DM). An increase from being inactive to achieving recommended PA levels (150 minutes of moderate-intensity aerobic activity per week) was associated with lower risk of CVD mortality by 23%, CVD incidence by 17%, and T2DM incidence by 26% (relative risk [RR], 0.77 [0.71-0.84]), (RR, 0.83 [0.77-0.89]), and (RR, 0.74 [0.72-0.77]), respectively, after adjustment for body weight.

CONCLUSIONS: By using a single continuous metric for PA levels, we were able to make a comparison of the effect of PA on CVD incidence and mortality including myocardial infarct (MI), stroke, and heart failure, as well as T2DM. Effect sizes were generally similar for CVD and T2DM, and suggested that the greatest gain in health is associated with moving from inactivity to small amounts of PA.
Language eng
DOI 10.1161/JAHA.115.002495
Field of Research 111799 Public Health and Health Services not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution non-commercial licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30087869

Document type: Journal Article
Collections: Faculty of Health
Population Health
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.