Postprandial responses to lipid and carbohydrate ingestion in repeated subcutaneous adipose tissue biopsies in healthy adults Dordevic, Aimee L., Pendergast, Felicity J., Morgan, Han, Villas-Boas, Silas, Caldow, Marissa K., Larsen, Amy E., Sinclair, Andrew J. and Cameron-Smith, David 2015, Postprandial responses to lipid and carbohydrate ingestion in repeated subcutaneous adipose tissue biopsies in healthy adults, Nutrients, vol. 7, no. 7, pp. 5347-5361, doi: 10.3390/nu7075224. Attached Files Name Description MIMEType Size Downloads dordevic-postprandial-2015.pdf Published version application/pdf 582.05KB 94 Title Postprandial responses to lipid and carbohydrate ingestion in repeated subcutaneous adipose tissue biopsies in healthy adults Author(s) Dordevic, Aimee L. Pendergast, Felicity J. Morgan, Han Villas-Boas, Silas Caldow, Marissa K. Larsen, Amy E. Sinclair, Andrew J. Cameron-Smith, David Journal name Nutrients Volume number 7 Issue number 7 Start page 5347 End page 5361 Total pages 15 Publisher MDPI Place of publication Basel, Switzerland Publication date 2015-07-01 ISSN 2072-6643 Keyword(s) adipokine adipose tissue biopsy inflammation postprandial Adult Beverages Body Mass Index Chemokine CCL2 Dietary Carbohydrates Dietary Fats Drinking Water Eating Female Healthy Volunteers Humans Interleukin-6 Leptin Lipids Male Postprandial Period Subcutaneous Fat, Abdominal Time Factors Tumor Necrosis Factor-alpha Young Adult Summary Adipose tissue is a primary site of meta-inflammation. Diet composition influences adipose tissue metabolism and a single meal can drive an inflammatory response in postprandial period. This study aimed to examine the effect lipid and carbohydrate ingestion compared with a non-caloric placebo on adipose tissue response. Thirty-three healthy adults (age 24.5 ± 3.3 year (mean ± standard deviation (SD)); body mass index (BMI) 24.1 ± 3.2 kg/m2, were randomised into one of three parallel beverage groups; placebo (water), carbohydrate (maltodextrin) or lipid (dairy-cream). Subcutaneous, abdominal adipose tissue biopsies and serum samples were collected prior to (0 h), as well as 2 h and 4 h after consumption of the beverage. Adipose tissue gene expression levels of monocyte chemoattractant protein-1 (MCP-1), interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α) increased in all three groups, without an increase in circulating TNF-α. Serum leptin (0.6-fold, p = 0.03) and adipose tissue leptin gene expression levels (0.6-fold, p = 0.001) decreased in the hours following the placebo beverage, but not the nutrient beverages. Despite increased inflammatory cytokine gene expression in adipose tissue with all beverages, suggesting a confounding effect of the repeated biopsy method, differences in metabolic responses of adipose tissue and circulating adipokines to ingestion of lipid and carbohydrate beverages were observed. Language eng DOI 10.3390/nu7075224 Field of Research 1111 Nutrition And Dietetics Socio Economic Objective 0 Not Applicable HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2015, The Authors Free to Read? Yes Use Rights Persistent URL http://hdl.handle.net/10536/DRO/DU:30088064 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Open Access Collection Related Links Link Description Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Thu, 20 Oct 2016, 13:37:49 EST Thu, 27 Oct 2016, 08:31:40 EST Wed, 02 Aug 2017, 09:25:48 EST Wed, 02 Aug 2017, 09:31:21 EST Thu, 03 Aug 2017, 10:34:14 EST Wed, 13 Sep 2017, 06:07:28 EST Wed, 13 Sep 2017, 12:24:25 EST Fri, 07 Sep 2018, 12:44:54 EST Filtered Full Citation counts:   Cited 9 times in TR Web of Science Cited 9 times in Scopus Search Google Scholar Access Statistics: 281 Abstract Views, 95 File Downloads  -  Detailed Statistics Created: Thu, 20 Oct 2016, 13:37:49 EST

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