Electroactive nanostructured scaffold produced by controlled deposition of PPy on electrospun PCL fibres

Shafei, Sajjad, Foroughi, Javad, Stevens, Leo, Wong, Cynthia S, Zabihi, Omid and Naebe, Minoo 2017, Electroactive nanostructured scaffold produced by controlled deposition of PPy on electrospun PCL fibres, Research on chemical intermediates, vol. 43, no. 2, pp. 1235-1251, doi: 10.1007/s11164-016-2695-4.

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Title Electroactive nanostructured scaffold produced by controlled deposition of PPy on electrospun PCL fibres
Author(s) Shafei, Sajjad
Foroughi, Javad
Stevens, Leo
Wong, Cynthia S
Zabihi, OmidORCID iD for Zabihi, Omid orcid.org/0000-0001-8065-2671
Naebe, MinooORCID iD for Naebe, Minoo orcid.org/0000-0002-0607-6327
Journal name Research on chemical intermediates
Volume number 43
Issue number 2
Start page 1235
End page 1251
Total pages 17
Publisher Springer Verlag
Place of publication Berlin, Germany
Publication date 2017-02
ISSN 0922-6168
Keyword(s) PCL
Biodegradable polymer
Conductive polymer
Tissue engineering
Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Conducting polymer
Biomedical applications
Nanofibrous scaffolds
Composite nanofibres
Tissue regeneration
Summary The electrical conductivity of biodegradable polymeric scaffolds has shown promising results in tissue engineering, particularly for electrically excitable tissues such as muscles and nerves. Herein, we demonstrate a novel processing approach to produce electroactive nanofibres. Electrically conducting, robust nanofibres comprising both a biodegradable component using poly(ε-caprolactone) (PCL) and a conducting component, polypyrrole (PPy), have been produced by electrospinning and vapour phase polymerization. The PCL/PPy nanofibres were characterised in terms of morphology, electrical conductivity, and dimensional stability. The as-prepared nanofibres were found to be cytocompatible with good electrical conductivity and mechanical properties. It was found that electrical conductivity of the PPy coated PCL nanofibre was 1.9 S/cm, which is much higher than that of PCL mixed with PPy in other studies. Cell viability on the scaffolds were firstly examined by in vitro culturing the L929 fibroblast cells for 24 h, revealing viability of 97.6 ± 2.7 %. Then PC12 cells differentiation observed by neurite outgrowth which occurred after 4 days of culture on the scaffolds. Significantly larger areas of the PPy coated PCL were covered by cells compared to PCL without coating. The obtained results from filament staining suggested the high potentials of the conducting scaffold for use in neural tissue engineering.
Language eng
DOI 10.1007/s11164-016-2695-4
Field of Research 0306 Physical Chemistry (Incl. Structural)
Socio Economic Objective 0 Not Applicable
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2016, Springer Science+Business Media Dordrecht
Persistent URL http://hdl.handle.net/10536/DRO/DU:30088080

Document type: Journal Article
Collections: Institute for Frontier Materials
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