Deep brain stimulation mediates neurotrophin signaling in an animal model of antidepressant resistance REKER, ASHLIE 2016, Deep brain stimulation mediates neurotrophin signaling in an animal model of antidepressant resistance, PhD. thesis, School of Psychology, Deakin University. Attached Files Name Description MIMEType Size Downloads reker-deepbrain-2016A.pdf Connect to thesis application/pdf 7.50MB 220 Title Deep brain stimulation mediates neurotrophin signaling in an animal model of antidepressant resistance Author REKER, ASHLIE Institution Deakin University School School of Psychology Faculty Faculty of Health Degree type Research doctorate Degree name PhD. Thesis advisor Tye, Susannah McGillivray Jane orcid.org/0000-0003-2000-6488 Konstantopoulos Nicky Date submitted 2016-05 Keyword(s) Mental illness Anti-depressants Major depressive disorder Deep brain stimulation Psychotherapy Depression Summary Chronic adrenocorticotropic hormone administration at circadian nadir produces an antidepressant resistance animal model that does not present with an altered plasma corticosterone profile nor changes in hippocampal brain derived neurotrophic factor and its receptor. Acute and chronic infralimbic deep brain stimulation elicited an antidepressant response in this animal model, which appears to be associated with changes in gene and protein expression of key intracellular mediators of neurotrophic factor signaling. Together, these findings stand to make important positive impacts on treatment strategies for one of the most debilitating and prevalent disorders of the modern era and suggest that antidepressant treatment response may involve mechanisms distinct from chronic stress-mediated induction of depression-like behavioral phenotypes. Language eng Field of Research 110319 - Psychiatry (incl. Psychotherapy) 100% Socio Economic Objective 920111 - Nervous System and Disorders 100% Description of original 263 pages : tables, figures, some coloured, appendices. Copyright notice ©The Author. All Rights Reserved Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30089171 Document type: Thesis Collections: Higher degree theses (Open Access) Open Access Collection   Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 21 Nov 2016, 13:19:17 EST Thu, 24 Nov 2016, 08:16:55 EST Wed, 07 Dec 2016, 11:45:50 EST Wed, 07 Dec 2016, 11:47:37 EST Thu, 09 Mar 2017, 07:31:13 EST Thu, 09 Mar 2017, 09:30:29 EST Tue, 31 Jul 2018, 12:49:50 EST Fri, 07 Sep 2018, 18:54:23 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 255 Abstract Views, 225 File Downloads  -  Detailed Statistics Created: Mon, 21 Nov 2016, 13:19:09 EST by Deb Gray