Evolutionary ecology of organs: a missing link in cancer development?

Thomas, Frédéric, Nesse, Randolph M, Gatenby, Robert, Gidoin, Cindy, Renaud, François, Roche, Benjamin and Ujvari, Beata 2016, Evolutionary ecology of organs: a missing link in cancer development?, Trends in cancer, vol. 2, no. 8, pp. 409-415, doi: 10.1016/j.trecan.2016.06.009.

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Title Evolutionary ecology of organs: a missing link in cancer development?
Author(s) Thomas, Frédéric
Nesse, Randolph M
Gatenby, Robert
Gidoin, Cindy
Renaud, François
Roche, Benjamin
Ujvari, BeataORCID iD for Ujvari, Beata orcid.org/0000-0003-2391-2988
Journal name Trends in cancer
Volume number 2
Issue number 8
Start page 409
End page 415
Total pages 7
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-08
ISSN 2405-8033
Keyword(s) cancer
malignant transformation
intrinsic causes
extrinsic causes
organ ecology
Summary There is striking variation in the incidence of cancer in human organs. Malignant tumors are common in the colon and breast but rare in the heart and small bowel. The uterus frequently develops benign fibroid tumors but uterine cancers are relatively rare. The organ-specific difference in cancer prevalence has been explained primarily by the relative roles of intrinsic and extrinsic risk factors. In this opinion article, we propose also considering organs as distinct but connected ecosystems whose different vulnerabilities to malignant transformation may be partially explained by how essential each organ is for survival through the age of reproduction. We present and discuss some of the basic concepts and assumptions of this perspective on evolutionary medicine.
Language eng
DOI 10.1016/j.trecan.2016.06.009
Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified
119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier Inc.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30089540

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