A systematic review and meta-analysis of prospective transition from major depression to bipolar disorder Ratheesh, A, Davey, C, Hetrick, S, Alvarez-Jimenez, M, Voutier, C, Bechdolf, A, McGorry, PD, Scott, J, Berk, Michael and Cotton, SM 2017, A systematic review and meta-analysis of prospective transition from major depression to bipolar disorder, Acta psychiatrica Scandinavica, vol. 135, no. 4, pp. 273-284, doi: 10.1111/acps.12686. Attached Files Name Description MIMEType Size Downloads Title A systematic review and meta-analysis of prospective transition from major depression to bipolar disorder Author(s) Ratheesh, A Davey, C Hetrick, S Alvarez-Jimenez, M Voutier, C Bechdolf, A McGorry, PD Scott, J Berk, Michael orcid.org/0000-0002-5554-6946 Cotton, SM Journal name Acta psychiatrica Scandinavica Volume number 135 Issue number 4 Start page 273 End page 284 Total pages 12 Publisher Wiley-Blackwell Place of publication London, Eng. Publication date 2017-04 ISSN 0001-690X 1600-0447 Keyword(s) affective disorders bipolar disorder depression meta-analysis risk factors science & technology life sciences & biomedicine psychiatry prospective follow-up psychotic features diagnostic conversion unipolar depression prodromal features mood disorders risk-factors predictors illness mania Summary Some people with major depressive disorder (MDD) may be at a pre-onset stage for bipolar disorder (BD), where early identification or prevention efforts may be feasible. We aimed to identify rates and characteristics predictive of transition to BD in prospective follow-up studies of people with MDD. Using a systematic search strategy, we identified studies with a diagnostic ascertainment of MDD and BD of an adequate standard, and where the minimum length of follow-up was 6 months. We examined the incidence and point prevalence of BD and the pooled odds ratios (OR) for baseline predictors. From 5554 unique publications, 56 were included. Nearly a quarter of adults (22.5%) and adolescents with MDD followed up for a mean length of 12-18 years developed BD, with the greatest risk of transition being in the first 5 years. The meta-analysis identified that transition from MDD to BD was predicted by family history of BD (OR = 2.89, 95% CI: 2.01-4.14, N = 7), earlier age of onset of depression (g = -0.33, SE = 0.05, N = 6) and presence of psychotic symptoms (OR = 4.76, 95% CI: 1.79-12.66, N = 5). Participants with the identified risk factors merit closer observation and may benefit from prevention efforts, especially if outcomes broader than BD are considered. Language eng DOI 10.1111/acps.12686 Field of Research 110319 Psychiatry (incl Psychotherapy) 11 Medical And Health Sciences 17 Psychology And Cognitive Sciences Socio Economic Objective 920410 Mental Health HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2017, John Wiley & Sons A/S. Persistent URL http://hdl.handle.net/10536/DRO/DU:30091208 Document type: Journal Article Collections: Faculty of Health School of Medicine Related Links Link Description Connect to published version Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 13 Feb 2017, 10:43:46 EST Tue, 14 Feb 2017, 04:00:29 EST Tue, 14 Feb 2017, 09:33:45 EST Sat, 01 Apr 2017, 01:30:30 EST Wed, 05 Apr 2017, 06:05:43 EST Mon, 19 Jun 2017, 15:32:29 EST Mon, 19 Jun 2017, 15:37:02 EST Mon, 19 Jun 2017, 15:37:57 EST Filtered Full Citation counts:   Cited 59 times in TR Web of Science Cited 67 times in Scopus Search Google Scholar Access Statistics: 420 Abstract Views, 6 File Downloads  -  Detailed Statistics Created: Mon, 13 Feb 2017, 10:43:46 EST