Intestinal dysbiosis, gut hyperpermeability and bacterial translocation: missing links between depression, obesity and type 2 diabetes Slyepchenko, Anastasiya, Maes, Michael, Machado-Vieira, Rodrigo, Anderson, George, Solmi, Marco, Sanz, Yolanda, Berk, Michael, Köhler, Cristiano A. and Carvalho, Andre F. 2016, Intestinal dysbiosis, gut hyperpermeability and bacterial translocation: missing links between depression, obesity and type 2 diabetes, Current pharmaceutical design, vol. 22, no. 40, pp. 6087-6106, doi: 10.2174/1381612822666160922. Attached Files Name Description MIMEType Size Downloads Title Intestinal dysbiosis, gut hyperpermeability and bacterial translocation: missing links between depression, obesity and type 2 diabetes Author(s) Slyepchenko, Anastasiya Maes, Michael Machado-Vieira, Rodrigo Anderson, George Solmi, Marco Sanz, Yolanda Berk, Michael orcid.org/0000-0002-5554-6946 Köhler, Cristiano A. Carvalho, Andre F. Journal name Current pharmaceutical design Volume number 22 Issue number 40 Start page 6087 End page 6106 Total pages 22 Publisher Bentham Science Publishers Place of publication Bussum, The Netherlands Publication date 2016 ISSN 1873-4286 Keyword(s) microbiome gut probiotics type 2 diabetes mellitus obesity metabolic syndrome major depressive disorder psychiatry Summary The comorbid prevalence of major depressive disorder (MDD) with obesity and type II diabetes mellitus reflects the existence of a subset of individuals with a complex common pathophysiology and overlapping risk factors. Such comorbid disease presentations imply a number of difficulties, including: decreased treatment responsivity and adherence; altered glycemic control and increased risk of wider medical complications. A number of factors link MDD to metabolic-associated disorders, including: higher rates of shared risk factors such as poor diet and physical inactivity and biological elements including increased inflammation; insulin resistance; oxidative and nitrosative stress; and mitochondrial dysfunction. All of these biological factors have been extensively investigated in the pathophysiology of obesity and type 2 diabetes mellitus as well as MDD. In this review, we aim to: (1) overview the epidemiological links between MDD, obesity and type 2 diabetes mellitus; (2) discuss the role of synergistic neurotoxic effects in MDD comorbid with obesity, and type 2 diabetes mellitus; (3) review evidence of intestinal dysbiosis, leaky gut and increased bacterial translocation, in the pathophysiology of MDD, obesity and type 2 diabetes mellitus; and (4) propose a model in which the gut-brain axis could play a pivotal role in the comorbidity of these disorders. Language eng DOI 10.2174/1381612822666160922 Field of Research 110319 Psychiatry (incl Psychotherapy) 1115 Pharmacology And Pharmaceutical Sciences Socio Economic Objective 920410 Mental Health HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2016, Bentham Science Publishers Persistent URL http://hdl.handle.net/10536/DRO/DU:30091234 Document type: Journal Article Collections: Faculty of Health School of Medicine Related Links Link Description Connect to published version Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Tue, 14 Feb 2017, 10:01:27 EST Tue, 14 Feb 2017, 10:03:07 EST Wed, 15 Feb 2017, 04:00:22 EST Wed, 15 Feb 2017, 07:18:47 EST Sat, 25 Feb 2017, 05:06:35 EST Wed, 08 Mar 2017, 08:05:51 EST Wed, 08 Mar 2017, 08:10:46 EST Filtered Full Citation counts:   Cited 60 times in TR Web of Science Cited 66 times in Scopus Search Google Scholar Access Statistics: 483 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Tue, 14 Feb 2017, 10:03:07 EST