Single-step coprocessing of cohesive powder via mechanical dry coating for direct tablet compression

Qu, Li, Stewart, Peter J., Hapgood, Karen P., Lakio, Satu, Morton, David A.V. and Zhou, Qi (Tony) 2017, Single-step coprocessing of cohesive powder via mechanical dry coating for direct tablet compression, Journal of pharmaceutical sciences, vol. 106, no. 1, pp. 159-167, doi: 10.1016/j.xphs.2016.07.017.

Title Single-step coprocessing of cohesive powder via mechanical dry coating for direct tablet compression
Author(s) Qu, Li
Stewart, Peter J.
Hapgood, Karen P.ORCID iD for Hapgood, Karen P.
Lakio, Satu
Morton, David A.V.
Zhou, Qi (Tony)
Journal name Journal of pharmaceutical sciences
Volume number 106
Issue number 1
Start page 159
End page 167
Total pages 9
Publisher Elsevier
Place of publication New York, N.Y.
Publication date 2017-01
ISSN 0022-3549
Keyword(s) fine cohesive powder
mechanical dry coating
direct compression
Summary This study aims at testing the feasibility of a single-step coating process to produce a powder formulation of active and inactive ingredients for direct compression. A cohesive ibuprofen powder was coprocessed with a coating material, a binder (polyvinylpyrrolidone K25), and a superdisintegrant (crospovidone). Magnesium stearate (MgSt), l-leucine, and silica were selected as coating materials (1% w/w). A coprocessed powder without any coating material was employed as a control. Coating with MgSt, l-leucine, or silica produced significantly improved powder flow in comparison to the control batch. Robust tablets were produced from the processed powders for each coating material. The tablets compacted using the coated powders with MgSt or l-leucine also exhibited significantly lower tablet ejection forces than the control batch, demonstrating their lubrication effect. Furthermore, the disintegration time and dissolution rates of these tablets made of the formulations coprocessed with lubricants were enhanced, even for those coated with the hydrophobic material such as MgSt that has been previously reported to inhibit dissolution. However, the tablets made with silica-coated powders would not disintegrate. This study indicated the feasibility of a single-step dry coating process to produce powders with both flow-aid and lubrication effects, which are suitable for direct compression.
Language eng
DOI 10.1016/j.xphs.2016.07.017
Field of Research 1115 Pharmacology And Pharmaceutical Sciences
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2016, American Pharmacists Association
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