Can genetic-based advice help you lose weight? Findings from the Food4Me European randomized controlled trial Celis-Morales, Carlos, Marsaux, Cyril F.M., Livingstone, Katherine M., Navas-Carretero, Santiago, San-Cristobal, Rodrigo, Fallaize, Rosalind, Macready, Anna L., O'Donovan, Clare, Woolhead, Clara, Forster, Hannah, Kolossa, Silvia, Daniel, Hannelore, Moschonis, George, Mavrogianni, Christina, Manios, Yannis, Surwillo, Agnieszka, Traczyk, Iwona, Drevon, Christian A., Grimaldi, Keith, Bouwman, Jildau, Gibney, Mike J., Walsh, Marianne C., Gibney, Eileen R., Brennan, Lorraine, Lovegrove, Julie A., Martinez, J. Alfredo, Saris, Wim H.M. and Mathers, John C. 2017, Can genetic-based advice help you lose weight? Findings from the Food4Me European randomized controlled trial, American journal of clinical nutrition, vol. 105, no. 5, pp. 1204-1213, doi: 10.3945/ajcn.116.145680. Attached Files Name Description MIMEType Size Downloads Title Can genetic-based advice help you lose weight? Findings from the Food4Me European randomized controlled trial Author(s) Celis-Morales, Carlos Marsaux, Cyril F.M. Livingstone, Katherine M. orcid.org/0000-0002-9682-7541 Navas-Carretero, Santiago San-Cristobal, Rodrigo Fallaize, Rosalind Macready, Anna L. O'Donovan, Clare Woolhead, Clara Forster, Hannah Kolossa, Silvia Daniel, Hannelore Moschonis, George Mavrogianni, Christina Manios, Yannis Surwillo, Agnieszka Traczyk, Iwona Drevon, Christian A. Grimaldi, Keith Bouwman, Jildau Gibney, Mike J. Walsh, Marianne C. Gibney, Eileen R. Brennan, Lorraine Lovegrove, Julie A. Martinez, J. Alfredo Saris, Wim H.M. Mathers, John C. Journal name American journal of clinical nutrition Volume number 105 Issue number 5 Start page 1204 End page 1213 Total pages 10 Publisher American Society for Nutrition Place of publication Bethesda, Md. Publication date 2017-05 ISSN 1938-3207 Keyword(s) FTO genotype personalized nutrition randomized controlled trial weight Summary Background: There has been limited evidence about whether genotype-tailored advice provides extra benefits in reducing obesity-related traits compared with the benefits of conventional one-size-fits-all advice.Objective: We determined whether the disclosure of information on fat-mass and obesity-associated (FTO) genotype risk had a greater effect on a reduction of obesity-related traits in risk carriers than in nonrisk carriers across different levels of personalized nutrition.Design: A total of 683 participants (women: 51%; age range: 18-73 y) from the Food4Me randomized controlled trial were included in this analysis. Participants were randomly assigned to 4 intervention arms as follows: level 0, control group; level 1, dietary group; level 2, phenotype group; and level 3, genetic group. FTO (single nucleotide polymorphism rs9939609) was genotyped at baseline in all participants, but only subjects who were randomly assigned to level 3 were informed about their genotypes. Level 3 participants were stratified into risk carriers (AA/AT) and nonrisk carriers (TT) of the FTO gene for analyses. Height, weight, and waist circumference (WC) were self-measured and reported at baseline and months 3 and 6.Results: Changes in adiposity markers were greater in participants who were informed that they carried the FTO risk allele (level 3 AT/AA carriers) than in the nonpersonalized group (level 0) but not in the other personalized groups (level 1 and 2). Mean reductions in weight and WC at month 6 were greater for FTO risk carriers than for noncarriers in the level 3 group [-2.28 kg (95% CI: -3.06, -1.48 kg) compared with -1.99 kg (-2.19, -0.19 kg), respectively (P = 0.037); and -4.34 cm (-5.63, -3.08 cm) compared with -1.99 cm (-4.04, -0.05 cm), respectively, (P = 0.048)].Conclusions: There are greater body weight and WC reductions in risk carriers than in nonrisk carriers of the FTO gene. This trial was registered at clinicaltrials.gov as NCT01530139. Language eng DOI 10.3945/ajcn.116.145680 Field of Research 111199 Nutrition and Dietetics not elsewhere classified 11 Medical And Health Sciences 09 Engineering Socio Economic Objective 0 Not Applicable HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2017, American Society for Nutrition Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30094127 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Institute for Physical Activity and Nutrition Open Access Collection Related Links Link Description Link to full-text (open access)   Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. 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