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Passiflora incarnata treatment during gestation and lactation: toxicological and antioxidant evaluation in wistar dams

Boll, Karine Maria, Bortolasci, Chiara Cristina, Zaminelli, Tiago, Veríssimo, Luiz Fernando, Bacchi, André Demambre, Higachi, Luciana, Barbosa, Décio Sabbatini and Moreira, Estefânia Gastaldello 2014, Passiflora incarnata treatment during gestation and lactation: toxicological and antioxidant evaluation in wistar dams, Brazilian journal of pharmaceutical sciences, vol. 50, no. 2, Apr/Jun 2014, pp. 353-359, doi: 10.1590/S1984-82502014000200015.

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Title Passiflora incarnata treatment during gestation and lactation: toxicological and antioxidant evaluation in wistar dams
Formatted title Passiflora incarnata treatment during gestation and lactation: toxicological and antioxidant evaluation in wistar dams
Author(s) Boll, Karine Maria
Bortolasci, Chiara CristinaORCID iD for Bortolasci, Chiara Cristina orcid.org/0000-0002-0794-6363
Zaminelli, Tiago
Veríssimo, Luiz Fernando
Bacchi, André Demambre
Higachi, Luciana
Barbosa, Décio Sabbatini
Moreira, Estefânia Gastaldello
Journal name Brazilian journal of pharmaceutical sciences
Volume number 50
Issue number 2
Season Apr/Jun 2014
Start page 353
End page 359
Total pages 7
Publisher Universidade de Sao Paulo
Place of publication Sao Paulo, Brazil
Publication date 2014-04
ISSN 1984-8250
2175-9790
Keyword(s) phytomedicines/evaluation
Passiflora incarnata/use in pregnancy
Passiflora incarnata/ use in lactation
Passiflora incarnata/reproductive toxicity/experimental study
pregnancy/use of phytomedicines
lactation/use of phytomedicines
oxidative stress
Summary Passiflora incarnata is marketed in many countries as a phytomedicine. Even though the directions of most marketed phytomedicines recommend them to be used under medical supervision, reproductive and developmental studies are sparse and not mandatory for regulatory purposes. In this study, a reproductive toxicity evaluation of P. incarnata was conducted in Wistar rats gavaged (30 or 300 mg/kg) during pregnancy and lactation. Moreover, considering that antioxidant properties have been attributed to flavonoids present in the genus Passiflora, it was also evaluated the antioxidant/pro-oxidant balance in the plasma of these dams and the antioxidant potential in an in vitro test. P. incarnata treatment did not influence dams´ body weight as well as reproductive (gestation length, post-implantation loss, litter size, litter weight) and hepatic (albumin, AST, ALT, GGT) parameters. The antioxidant property of P. incarnata was evidenced both in vivo (increase in the total antioxidant plasmatic potential) and in vitro (decrease in neutrophil-induced respiratory burst). The results from the present study indicate that under the experimental conditions evaluated, P. incarnata treatment during gestation and lactation presented antioxidant activity in the absence of maternal reproductive toxicity.
Language eng
DOI 10.1590/S1984-82502014000200015
Field of Research 1115 Pharmacology And Pharmaceutical Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2014, Brazilian Journal of Pharmaceutical Sciences
Free to Read? Yes
Use Rights Creative Commons Attribution non-commercial licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30095963

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.